Q0T5Z6 · YMDB_SHIF8
- ProteinO-acetyl-ADP-ribose deacetylase
- GeneymdB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids177 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
Catalytic activity
- 3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11-12 | substrate | ||||
Sequence: DI | ||||||
Binding site | 25 | substrate | ||||
Sequence: N | ||||||
Binding site | 33-35 | substrate | ||||
Sequence: GVD | ||||||
Active site | 35 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 122-126 | substrate | ||||
Sequence: STGVY |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | deacetylase activity | |
Molecular Function | purine nucleoside binding | |
Molecular Function | ribonuclease inhibitor activity | |
Biological Process | purine nucleoside metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameO-acetyl-ADP-ribose deacetylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Shigella
Accessions
- Primary accessionQ0T5Z6
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000409487 | 1-177 | O-acetyl-ADP-ribose deacetylase | |||
Sequence: MKTRIHVVQGDITKLAVDVIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDCPTGHAVITLAGDLPAKAVVHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPAISTGVYSYPRAAAAEIAVKTVSEFITRHALPEQVYFVCYDEENAHLYERLLTQQGDE |
Interaction
Subunit
Homodimer. Interacts with RNase III.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-175 | Macro | ||||
Sequence: MKTRIHVVQGDITKLAVDVIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDCPTGHAVITLAGDLPAKAVVHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPAISTGVYSYPRAAAAEIAVKTVSEFITRHALPEQVYFVCYDEENAHLYERLLTQQG |
Sequence similarities
Belongs to the YmdB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length177
- Mass (Da)18,910
- Last updated2006-09-05 v1
- Checksum6F4E09A31AF70AAF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000266 EMBL· GenBank· DDBJ | ABF03269.1 EMBL· GenBank· DDBJ | Genomic DNA |