Q0S8D5 · PANC_RHOJR

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site42-49ATP (UniProtKB | ChEBI)
Active site49Proton donor
Binding site73(R)-pantoate (UniProtKB | ChEBI)
Binding site73beta-alanine (UniProtKB | ChEBI)
Binding site159-162ATP (UniProtKB | ChEBI)
Binding site165(R)-pantoate (UniProtKB | ChEBI)
Binding site188ATP (UniProtKB | ChEBI)
Binding site196-199ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • Ordered locus names
      RHA1_ro04415

Organism names

Accessions

  • Primary accession
    Q0S8D5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003055291-312Pantothenate synthetase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    312
  • Mass (Da)
    32,922
  • Last updated
    2006-09-05 v1
  • MD5 Checksum
    51849D3B26D3FA787A001BE249A54D3E
MSDLQGGYKRGELTVHHDPSVLTRVSKALRGVGRQVALVPTMGALHTGHLELVRQAKLTGAVVIVSIFVNPLQFGAGEDLDAYPRTLDADLELLREAGVELAFVPTAATMYPAGPRTTIHPGPLGAELEGVSRPTHFAGMLTVVAKLLQIAAPNVAYFGEKDYQQLTLIRQMVTDLNFDVRIFGVPTVREHDGLALSSRNRYLDEAQRSAATALSAALIAGAHAAAGGAEAILATAREVLASVPEVEVDYLEVRGVDLGPAPERGDGRLLVAAKVGTTRLIDNVGVAVGTGFLERDAEPPSDASAADELLSR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000431
EMBL· GenBank· DDBJ
ABG96201.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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