Q0RB94 · PANC4_FRAAA
- ProteinPantothenate synthetase 4
- GenepanC4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids302 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Miscellaneous
The reaction proceeds by a bi uni uni bi ping pong mechanism.
Catalytic activity
- (R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H+
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 51-58 | ATP (UniProtKB | ChEBI) | ||||
Sequence: MGALHEGH | ||||||
Active site | 58 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 82 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 82 | beta-alanine (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 166-169 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GRKD | ||||||
Binding site | 172 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 195 | ATP (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 203-206 | ATP (UniProtKB | ChEBI) | ||||
Sequence: RSSR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | pantoate-beta-alanine ligase activity | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePantothenate synthetase 4
- EC number
- Short namesPS 4
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Frankiales > Frankiaceae > Frankia
Accessions
- Primary accessionQ0RB94
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000305456 | 1-302 | Pantothenate synthetase 4 | |||
Sequence: MLVRDRAELRAALVALDRAASSHPPAAAQDAGPARAASRHDRPVRAVVMTMGALHEGHASLLRAARARADQVVATIFVNPLQFGAGEDLDRYPRTLAADLAVCAREGVDVVFAPAVIHDPPPLVRFGAGPLGAVLEGASRPGHFDGMLTLVGTMLHLVQPDLAFFGRKDAQQLVCIRRMVADLAFDVTVIGVETAREPDGLARSSRNVYLTAEQRTEALALSRALAAGAAASADGAPAVLAAARAVLDAADGVDVDYLELAGPEDLGPVRGGPALLLVAARVGTTRLIDNVSLILPTDTQGA |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length302
- Mass (Da)31,350
- Last updated2006-09-05 v1
- ChecksumCD83BD88735FEE29
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CT573213 EMBL· GenBank· DDBJ | CAJ65293.1 EMBL· GenBank· DDBJ | Genomic DNA |