Q0R606 · Q0R606_MACNP

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Molecular Functionubiquinone binding
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number

Gene names

    • Name
      ND5

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q0R606

Subcellular Location

Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-27Helical
Transmembrane39-62Helical
Transmembrane74-97Helical
Transmembrane103-123Helical
Transmembrane130-153Helical
Transmembrane159-180Helical
Transmembrane187-207Helical
Transmembrane227-255Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-247NADH:quinone oxidoreductase/Mrp antiporter membrane subunit

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    302
  • Mass (Da)
    32,536
  • Last updated
    2006-09-05 v1
  • Checksum
    D7E460CD04A1ED58
IALFGSLPLLISILSLYSTGGSVTFNLSSLPECGTSLMAVWYICSVMAFIVKLPVYLVHLWLPKAHVEAPVAGSMILAGVLLKLGGYGLVRVCPLFIQPAVTFSWFWVSVGLLGGIFVSFICLRQTDMKALIAYSSVAHMGLVLCGLSVFSWWGLSGAVSVMVGHGLCSSGLFCLANMVYERLGSRSLLISKGLLSFMPTMALWWFVLSAGNMAAPPTVNLLGEISLILSVVSWALLAMVPVALLSFLSAAYSLYMFSLSQHGKYFSALFSCCSGKVREYLILILHWLPLNVLVLKGSVLVC

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ017215
EMBL· GenBank· DDBJ
AAZ20741.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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