Q0PMN1 · Q0PMN1_MOUSE
- ProteinInterleukin-6
- GeneIl6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids211 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Publications for Q0PMN1
Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor.
- CategoriesFunction, Interaction
- SourceMGI: 96559
- PubMed
- Europe PMC
- Blood 83:3457-3461 ()
Mapped toRequirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter.
- CategoriesSequences, Interaction
- SourceMGI: 96559
- PubMed
- Europe PMC
- Blood 83:2469-2479 ()
Mapped toActivated granulocytes and inflammatory cytokine signaling drive T-cell lymphoma progression and disease symptoms.
- CategoriesFamily & Domains, Interaction, Phenotypes & Variants
- SourceMGI: 96559
Interleukin-6 promotes microtubule stability in axons via Stat3 protein- protein interactions.
- CategoriesFunction, Interaction
- SourceMGI: 96559
Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
- AnnotationConverged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
- CategoryInteraction
- SourceGeneRif: 16193
HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.
- AnnotationHMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.
- CategoriesFunction, Interaction
- SourceGeneRif: 16193
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
- CategoriesFunction, Interaction
- SourceMGI: 96559
KDM2B promotes IL-6 production and inflammatory responses through Brg1- mediated chromatin remodeling.
- AnnotationKDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling.
- CategoriesFunction, Interaction
Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.
- AnnotationIL-6-STAT3 signaling facilitates TRIM28 binding to the Il17-Il17f locus and this process is required for epigenetic activation and high-order chromosomal interaction in autoimmune experimental encephalomyelitis.
- CategoriesFunction, Interaction
Association of HSP22 with mTOR in osteoblasts: regulation of TNF-alpha- stimulated IL-6 synthesis.
- AnnotationThese results strongly suggest that HSP22 interacts with mTOR and regulates TNF-alpha-induced IL-6 synthesis in osteoblasts.
- CategoriesFunction, Interaction
- SourceGeneRif: 16193
SorLA in Interleukin-6 Signaling and Turnover.
- AnnotationSorLA ectodomain released from the cell membrane upon enzymatic cleavage of full-length SorLA may act as an IL-6 carrier protein that stabilizes IL-6 and its capacity for trans signaling.
- CategoryInteraction
SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.
- AnnotationIn macrophages SCIMP is constitutively associated with the Lyn tyrosine kinase is required for tyrosine phosphorylation of TLR4 and facilitates TLR-inducible production of the IL-6 and IL-12p40.
- CategoryInteraction
Interleukin (IL)-6 modulates transforming growth factor-beta receptor I and II (TGF-betaRI and II) function in epidermal keratinocytes.
- Annotationrole in keratinocyte migration and proliferation through modulation of TGF-betaR expression and function
- CategoriesFunction, Expression, Interaction
- SourceGeneRif: 16193
Adipose-Derived Stem Cells Enhance Cancer Stem Cell Property and Tumor Formation Capacity in Lewis Lung Carcinoma Cells Through an Interleukin-6 Paracrine Circuit.
- AnnotationAdipose-derived stem cells play a pro-malignant role in tumor development of Lewis lung carcinoma cells by particularly promoting cancer stem cell property through interleukin-6 paracrine circuit.
- CategoriesFunction, Interaction
- SourceGeneRif: 16193
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD.
- CategoryInteraction
- SourceMGI: 96559
Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex.
- AnnotationThe IL-6 signaling complex is a hexamer formed by the association of two IL-6.IL-6 receptor (IL-6R).gp130 trimers with gp130 being the signal transducer inducing cis- and trans-mediated signaling via a membrane-bound or soluble form of the IL-6R.
- CategoriesFunction, Interaction
BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.
- CategoriesFunction, Interaction
- SourceMGI: 96559
The role of tumor suppressor menin in IL-6 regulation in mouse islet tumor cells.
- AnnotationExpression of IL-6 a proinflammatory cytokine was specifically elevated in islet tumor cells upon depletion of menin and in Men(-/-) MEF cells but not in hepatocellular carcinoma cells.
- CategoryInteraction
Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO.
- Annotationreport that Rhbdd3 a member of the rhomboid family of proteases suppressed the activation of dendritic cells and production of interleukin 6 (IL-6) triggered by Toll-like receptors
- CategoriesFunction, Interaction
RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription.
- AnnotationResults show that RMP serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 transcription.
- CategoryInteraction
- SourceGeneRif: 16193
Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages.
- AnnotationDaxx selectively represses IL-6 transcription through HDAC1-mediated histone deacetylation
- CategoryInteraction
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.
- CategoryInteraction
- SourceMGI: 96559
CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production.
- Annotationfibrin production pathogen control and survival of Lm-infected WT mice illustrating that therapeutic inhibition of CYLD augments the protective NF-kappaB/IL-6/STAT3 pathway and fibrin production.
- CategoriesFunction, Interaction