Interruption of immunoregulatory axis results in demyelination of the optic nerve the spinal cord and the brain by autoreactive T cells in the HSV-IL-2 mouse model of multiple sclerosis.
Data show that IL-2 derived from CD4+ helper T cells cooperates with innate immune cell-derived IL-27 to amplify IL-10 production by CTLs through a Blimp-1-dependent mechanism.
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