Q0MQI4 · NDUV1_PONPY
- ProteinNADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
- GeneNDUFV1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids464 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster.
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)This reaction proceeds in the forward direction.
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FMN.
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 87-96 | NADH (UniProtKB | ChEBI) | |||
Binding site | 199-247 | FMN (UniProtKB | ChEBI) | |||
Binding site | 379 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 382 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 385 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 425 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex I | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | FMN binding | |
Molecular Function | metal ion binding | |
Molecular Function | NAD binding | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | mitochondrial electron transport, NADH to ubiquinone |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo
Accessions
- Primary accessionQ0MQI4
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for transit peptide, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-20 | Mitochondrion | |||
Chain | PRO_0000251878 | 21-464 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | ||
Modified residue | 81 | N6-acetyllysine; alternate | |||
Modified residue | 81 | N6-succinyllysine; alternate | |||
Modified residue | 104 | N6-acetyllysine | |||
Modified residue | 257 | Omega-N-methylarginine | |||
Modified residue | 375 | N6-acetyllysine | |||
Keywords
- PTM
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity).
This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).
Interacts with RAB5IF (By similarity).
This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).
Interacts with RAB5IF (By similarity).
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length464
- Mass (Da)50,727
- Last updated2006-09-19 v1
- Checksum7F0B1F0440B1C4BA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ885650 EMBL· GenBank· DDBJ | ABH12159.1 EMBL· GenBank· DDBJ | mRNA |