Q0MQI4 · NDUV1_PONPY

  • Protein
    NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
  • Gene
    NDUFV1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site87-96NADH (UniProtKB | ChEBI)
Binding site199-247FMN (UniProtKB | ChEBI)
Binding site379[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site382[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site385[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site425[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex I
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
  • EC number
  • Alternative names
    • Complex I-51kD (CI-51kD)
    • NADH-ubiquinone oxidoreductase 51 kDa subunit

Gene names

    • Name
      NDUFV1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo

Accessions

  • Primary accession
    Q0MQI4

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

Type
IDPosition(s)Description
Transit peptide1-20Mitochondrion
ChainPRO_000025187821-464NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Modified residue81N6-acetyllysine; alternate
Modified residue81N6-succinyllysine; alternate
Modified residue104N6-acetyllysine
Modified residue257Omega-N-methylarginine
Modified residue375N6-acetyllysine

Keywords

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity).
This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).
Interacts with RAB5IF (By similarity).

Structure

Family & Domains

Sequence similarities

Belongs to the complex I 51 kDa subunit family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    464
  • Mass (Da)
    50,727
  • Last updated
    2006-09-19 v1
  • Checksum
    7F0B1F0440B1C4BA
MLAARRLLGWSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGALSRGDWYKTKEILLKGPDWILGEIKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNYPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDAQPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQHQAQQAAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ885650
EMBL· GenBank· DDBJ
ABH12159.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp