Q0IHQ8 · STK10_XENTR

Function

function

May act as a polo kinase kinase by mediating phosphorylation of plk1/plx1 and subsequent activation of plk1/plx1 during oocyte maturation.

Catalytic activity

Features

Showing features for binding site, active site.

1951100200300400500600700800900
TypeIDPosition(s)Description
Binding site42-50ATP (UniProtKB | ChEBI)
Binding site65ATP (UniProtKB | ChEBI)
Active site157Proton acceptor

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionprotein homodimerization activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processprotein autophosphorylation
Biological Processregulation of lymphocyte migration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase 10
  • EC number

Gene names

    • Name
      stk10

Organism names

Accessions

  • Primary accession
    Q0IHQ8
  • Secondary accessions
    • F7A3L3

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004147151-951Serine/threonine-protein kinase 10
Modified residue483Phosphoserine; by PLK1
Modified residue487Phosphoserine; by PLK1
Modified residue491Phosphoserine; by PLK1

Post-translational modification

Autophosphorylates. Phosphorylated by plk1/plx1, suggesting the existence of a feedback loop with plk1/plx1. activation of the protein (By similarity).

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain36-294Protein kinase
Region319-479Disordered
Compositional bias343-357Basic and acidic residues
Compositional bias373-395Basic and acidic residues
Compositional bias425-479Polar residues
Coiled coil583-723
Region785-804Disordered
Coiled coil898-928
Region930-951Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    951
  • Mass (Da)
    111,828
  • Last updated
    2006-10-03 v1
  • Checksum
    BB08720CABE2960D
MAFANFRRILRLPNFEKKRLREYEHVRRDLDPNQVWEIIGELGDGAFGKVYKAKNKETGILAAAKVIETKNEEELEDYMVEIEILATCNHHFIVKLLGSYYWEGKLWIMIEFCPGGAVDAIMLELDRGLKEPEIRTICRQMLEGLTYLHSMKMIHRDLKAGNVLLTLDGDIKLADFGVSAKNVKTLQRRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSEPPTLSSPSKWSPEFHNFLKTALDKNPETRPSAAQLLEHPFVKKVSGNKPLRDLVAEAKAEVLDEIEENGEVEEEEASDTPSSNKSVSQSALGEKDKHTGKEHVGNGIKAEPQNTDSQADIHSQKRNHEGKNYPEHNRHDAVNGKPDIIILNPVSSNHEPKRNSAAESYRNEEHGSAVSSNQRPKSSQSDRQSVELVPNGSFDSPTRYFTGWSKRDSDSGSNSASESMDISMNLSADLSINKETGSLSLRESRLHKKTLKRTRRFVVDGVEVSITTSKIIGDDEKKDEEMRFLRRQELRELRLLQKEEHRNQAQLTSKHSFQMEQMLRRFEQEMNSKRKFYDSELEALERHQKQQIERMEQEHALRRRDEARRIRTEQERDHVKFLEQLKLRKKELKAQVEKLPRQQRRDAMKVQMDDFAQKKHIEEQQFLNKQKEDLTLALRVIVLENRKEIYNKEREFLNKKQQLLRDREAVIWDLEERHLQERHQLVKQQLKDQYFLQRHELLRKHEKEQEQMQRYNQRMMEQLKLRQQQERARLPKNQKAEAKTRMTMFKKSLHISPSGSAAEQREKIKQFSLQEEKRQKAERLQQQQKHEHQLLEMQAECDCNVRDLLQMQNEKCHLLVEHETQKLKTLDEHHIQMIREWRENLRPRKKALEDELEHKKEEQEMFFRMNEEVAGHPFPSNKPAKFYSFSSPEAS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias343-357Basic and acidic residues
Compositional bias373-395Basic and acidic residues
Compositional bias425-479Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAMC01112142
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01112143
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01112144
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01112145
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC123019
EMBL· GenBank· DDBJ
AAI23020.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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