Q0IEN3 · TRMB_AEDAE
- ProteintRNA (guanine-N(7)-)-methyltransferase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids245 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.
Catalytic activity
- guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine
Pathway
tRNA modification; N7-methylguanine-tRNA biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 70 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 93-94 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 126-127 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 146 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Active site | 149 | ||||
Binding site | 224-226 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | tRNA methyltransferase complex | |
Molecular Function | tRNA (guanine(46)-N7)-methyltransferase activity | |
Molecular Function | tRNA binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA (guanine-N(7)-)-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Aedini > Aedes > Stegomyia
Accessions
- Primary accessionQ0IEN3
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000370564 | 1-245 | tRNA (guanine-N7-)-methyltransferase | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length245
- Mass (Da)28,519
- Last updated2006-10-03 v1
- ChecksumE02F7B6314752947
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6I8TH96 | A0A6I8TH96_AEDAE | 5571573 | 245 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH477558 EMBL· GenBank· DDBJ | EAT39016.1 EMBL· GenBank· DDBJ | Genomic DNA |