Q0IE79 · Q0IE79_SYNS3

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site29Nucleophile
Binding site271[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site318Mg2+ (UniProtKB | ChEBI)
Binding site380Mg2+ (UniProtKB | ChEBI)
Binding site381Mg2+ (UniProtKB | ChEBI)
Binding site417[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site468[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site471[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF
    • Ordered locus names
      sync_0004

Organism names

Accessions

  • Primary accession
    Q0IE79

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-254Glutamine amidotransferase type-2

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    501
  • Mass (Da)
    54,703
  • Last updated
    2006-10-03 v1
  • Checksum
    59E59E798B4F40A1
MQNLETHPKSRRPVHQLEIERPDRMEEACGVFAVQALEQPVANLVYFGLYALQHRGQESAGIAVFNEGKVRLHKDMGLVSQVFDQDVLERMPGGLAVGHNRYSTTGSSKVCNAQPVVLMTRLGPFALAHNGNLVNAAELRAQVDDGEVEFTSTTDSELIAYAVQQAVDGGLDWTEGIKVAASQCQGAFSLVIGTSDALYGLRDGYGIRPLVYGYLGEQDLGHWVLSSETCGLDIIGSPFVADVEPGELVVFRCGDPTPERHRWIEPTTRMCVFEMIYFARPDSRFFGESLYSYRQRIGQILARESAVDADLVIGVPDSGIPAAIGYSQSSGVPYADGLIKNRYVGRTFIQPTQAMREAGIRVKLNPLPDVLSGKRVLVIDDSIVRGTTSKKLVQALRDAGAIEVHMRISSPPVTHPCFYGIDTDTQDQLIAARLTLQEIEEHLKVDSLAYLSKEGMVEAAHAQSEHFCTACFDGNYPVPMDASIKASKLMLEPSGVAATNL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000435
EMBL· GenBank· DDBJ
ABI47034.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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