Q0IDM2 · Q0IDM2_SYNS3

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mg2+ or Mn2+ ion per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, site.

148250100150200250300350400450
Type
IDPosition(s)Description
Binding site114NADP+ (UniProtKB | ChEBI)
Binding site123D-threo-isocitrate (UniProtKB | ChEBI)
Binding site125D-threo-isocitrate (UniProtKB | ChEBI)
Binding site129D-threo-isocitrate (UniProtKB | ChEBI)
Binding site139D-threo-isocitrate (UniProtKB | ChEBI)
Binding site163D-threo-isocitrate (UniProtKB | ChEBI)
Site170Critical for catalysis
Site247Critical for catalysis
Binding site372Mg2+ (UniProtKB | ChEBI)
Binding site417NADP+ (UniProtKB | ChEBI)
Binding site456NADP+ (UniProtKB | ChEBI)
Binding site460NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionisocitrate dehydrogenase (NADP+) activity
Molecular Functionmagnesium ion binding
Molecular FunctionNAD binding
Biological Processglyoxylate cycle
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Isocitrate dehydrogenase [NADP]
  • EC number

Gene names

    • Name
      icd
    • Ordered locus names
      sync_0214

Organism names

Accessions

  • Primary accession
    Q0IDM2

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue110N6-succinyllysine
Modified residue123Phosphoserine
Modified residue152N6-acetyllysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-478Isopropylmalate dehydrogenase-like

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    482
  • Mass (Da)
    53,127
  • Last updated
    2006-10-03 v1
  • Checksum
    86A645DB97E388D4
MPPDGDPSMAQFEKLTAPTEGTPIRFENGQPVVANDPIIPFIRGDGTGVDIWPATQKVLDAAVAQAYKGEKNIKWFKIYAGDEACDLYGTYQYLPEDTLEAIRSFGVAIKGPLTTPIGGGIRSLNVALRQIFDLYCCVRPCRYYEGTPSPHKRPEDLDVIVYRENTEDIYMGIEWEADDPIGQELRKHLNEVVIPANGKLGKRQIPEGSGIGIKPVSKHGSQRHIRKAIQHALRLEGNKRHVTLVHKGNIMKFTEGAFRDWGYELATTEFRDVCITERESWILDNLDRDHSLSAQDNARMIEPGYDSLTPEKKEAIDSEVKEVLAAIGESHGYGKWKSMVLVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAMVGGLGMAPGANIGETAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEFLGWQEAADLITKGLSAAIKDKQVTYDLARLMEPKVDPVSCSGFADAIIERF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000435
EMBL· GenBank· DDBJ
ABI45038.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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