Q0I6L2 · Q0I6L2_SYNS3

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphomonoester.
    EC:3.1.26.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.

Features

Showing features for binding site.

125020406080100120140160180200220240
TypeIDPosition(s)Description
Binding site17Mg2+ 1 (UniProtKB | ChEBI)
Binding site17Mg2+ 2 (UniProtKB | ChEBI)
Binding site56Mg2+ 1 (UniProtKB | ChEBI)
Binding site81Mg2+ 1 (UniProtKB | ChEBI)
Binding site144Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication, removal of RNA primer

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease H
  • EC number
  • Short names
    RNase H

Gene names

    • Name
      rnhA
    • Ordered locus names
      sync_2722

Organism names

Accessions

  • Primary accession
    Q0I6L2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain8-152RNase H type-1
Region153-174Disordered

Sequence similarities

Belongs to the RNase H family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    250
  • Mass (Da)
    27,229
  • Last updated
    2006-10-03 v1
  • Checksum
    B489356E1D1C260E
MAEEPDGRGRVVAAATDGACSGNPGPGGWGALIRFEDGSVEEFGGADPATTNNRMELQAALATLQRLAELPLHPNLTLRTDSKYLIDGLGSWMAGWKRKGWRTAAGKPVLNQDLWQALDQARLAEVPLSYVKGHSGDPDNDRVDQIAVAYSKGRKQTPPSLASPSAAPPQPLVDSAPVSLQKLLTRMELADRLASGGYALTAVELAQLVEQPLNRLSERQGSWRWRDWMVEPVENDRWRLRRDPAGSTET

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000435
EMBL· GenBank· DDBJ
ABI47397.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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