Q0E940 · EIF3B_DROME
- ProteinEukaryotic translation initiation factor 3 subunit B
- GeneeIF3b
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids690 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | eukaryotic 43S preinitiation complex | |
Cellular Component | eukaryotic 48S preinitiation complex | |
Cellular Component | eukaryotic translation initiation factor 3 complex | |
Molecular Function | mRNA binding | |
Molecular Function | translation initiation factor activity | |
Molecular Function | translation initiation factor binding | |
Biological Process | follicle cell of egg chamber development | |
Biological Process | formation of cytoplasmic translation initiation complex | |
Biological Process | regulation of translational initiation | |
Biological Process | translational initiation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEukaryotic translation initiation factor 3 subunit B
- Short nameseIF3b
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ0E940
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000363797 | 1-690 | Eukaryotic translation initiation factor 3 subunit B | |||
Sequence: MAKKKSEEHSGTDANDSDYQEEPNFDDPPGFVDNISDEDLLGDMLAQRPSEADGVESVVVVDNIPKVEPVRLEKLKLVINKLFSNYGEIVNVVYPVDEEGKTKGYAFMEYKQARQAEEAVKKLNNHRLDKNHTFAVNLFTDFQKYENIPEKWEPPTVQTFKVQSDLYNFINDPDTYDQYCVAAETAPNCVQVGFWQNVLPEPFELETRERFTDTFVKWSPLGTYVVTFHKPGVAIWGGSSFQKIQKFPHPGTQFVEFSPCENYLVTYGPTPTGQKIIIWDIRTGAEKRSFVADGMSVLSMFRWSHDDKFVARMGENSIHIYETPSFYLLDLKSIKIPGIRGFSWSPTDNVIAYWVEEQNQIPARVTLMEIPKKREIRNKNLFHVADCKLHWQKSGDYLCVKVDRYSKLKKDKKDLDVKFLGMFYNFEIFHMREKEIPVDSVEIRELILAFAWEPVGNKFSIIHGETNSSNVSFYEVNKGVKPSLVKRLEKKSCTHLFWSPRGQFIVMANLTMGTFEFVDSTNDYIITASPDHFRASEVEWDPTGRYVVTGVSSWKVKEDTGFNMYTFQGRIIKRTILKNFVQFLWRPRPPTLLSEEKQKEIKKNLKKYYAAFEQKDRLRLTRASKELLEKRSQLRETFMEYRNKRIAEWAEQKSRRIMLRGHVDTDNLETDEVDEEIVEFLVKEEVTLLE |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, repeat, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MAKKKSEEHSGTDAND | ||||||
Region | 1-33 | Disordered | ||||
Sequence: MAKKKSEEHSGTDANDSDYQEEPNFDDPPGFVD | ||||||
Domain | 57-141 | RRM | ||||
Sequence: SVVVVDNIPKVEPVRLEKLKLVINKLFSNYGEIVNVVYPVDEEGKTKGYAFMEYKQARQAEEAVKKLNNHRLDKNHTFAVNLFTD | ||||||
Repeat | 207-246 | WD 1 | ||||
Sequence: TRERFTDTFVKWSPLGTYVVTFHKPGVAIWGGSSFQKIQK | ||||||
Repeat | 293-331 | WD 2 | ||||
Sequence: DGMSVLSMFRWSHDDKFVARMGENSIHIYETPSFYLLDL | ||||||
Repeat | 334-369 | WD 3 | ||||
Sequence: IKIPGIRGFSWSPTDNVIAYWVEEQNQIPARVTLME | ||||||
Repeat | 442-484 | WD 4 | ||||
Sequence: EIRELILAFAWEPVGNKFSIIHGETNSSNVSFYEVNKGVKPSL | ||||||
Repeat | 530-575 | WD 5 | ||||
Sequence: PDHFRASEVEWDPTGRYVVTGVSSWKVKEDTGFNMYTFQGRIIKRT | ||||||
Coiled coil | 595-645 | |||||
Sequence: EEKQKEIKKNLKKYYAAFEQKDRLRLTRASKELLEKRSQLRETFMEYRNKR |
Sequence similarities
Belongs to the eIF-3 subunit B family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length690
- Mass (Da)80,441
- Last updated2006-10-17 v1
- ChecksumD7536C21C931D778
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E2QCG7 | E2QCG7_DROME | eIF3b | 690 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MAKKKSEEHSGTDAND | ||||||
Sequence conflict | 12 | in Ref. 3; AAM52578 | ||||
Sequence: T → A |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE013599 EMBL· GenBank· DDBJ | AAF57842.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY122066 EMBL· GenBank· DDBJ | AAM52578.1 EMBL· GenBank· DDBJ | mRNA | ||
BT072816 EMBL· GenBank· DDBJ | ACN62419.1 EMBL· GenBank· DDBJ | mRNA |