Q0CMB0 · ROK1_ASPTN
- ProteinATP-dependent RNA helicase rok1
- Generok1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids749 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 254-261 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Biological Process | maturation of SSU-rRNA |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent RNA helicase rok1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionQ0CMB0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000282701 | 1-749 | ATP-dependent RNA helicase rok1 | ||
Interaction
Subunit
Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-121 | Disordered | |||
Compositional bias | 8-39 | Polar residues | |||
Compositional bias | 100-121 | Basic and acidic residues | |||
Region | 148-182 | Disordered | |||
Compositional bias | 167-182 | Basic and acidic residues | |||
Motif | 192-224 | Q motif | |||
Domain | 241-457 | Helicase ATP-binding | |||
Region | 324-366 | Disordered | |||
Compositional bias | 333-352 | Acidic residues | |||
Motif | 404-407 | DEAD box | |||
Domain | 497-665 | Helicase C-terminal | |||
Compositional bias | 672-720 | Basic and acidic residues | |||
Region | 672-749 | Disordered | |||
Compositional bias | 724-741 | Polar residues | |||
Domain
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence similarities
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length749
- Mass (Da)82,178
- Last updated2007-04-03 v2
- Checksum01A90298CADEEC0C
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 8-39 | Polar residues | |||
Compositional bias | 100-121 | Basic and acidic residues | |||
Compositional bias | 167-182 | Basic and acidic residues | |||
Compositional bias | 333-352 | Acidic residues | |||
Compositional bias | 672-720 | Basic and acidic residues | |||
Compositional bias | 724-741 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH476600 EMBL· GenBank· DDBJ | EAU34243.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |