Q0CCX9 · GEDF_ASPTN

Function

function

Oxidoreductase; part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products (PubMed:19549600, PubMed:24009710, PubMed:7665560).
The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) gedC (PubMed:12536215, PubMed:19549600).
The atrochrysone carboxyl ACP thioesterase gedB then breaks the thioester bond and releases the atrochrysone carboxylic acid from gedC (PubMed:19549600).
The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodinanthrone (PubMed:24009710).
The next step is performed by the emodinanthrone oxygenase gedH that catalyzes the oxidation of emodinanthrone to emodin (PubMed:1810248).
Emodin O-methyltransferase encoded probably by gedA then catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:1444712).
Ring cleavage of questin by questin oxidase gedK leads to desmethylsulochrin via several intermediates including questin epoxide (PubMed:3182756).
Another methylation step probably catalyzed by methyltransferase gedG leads to the formation of sulochrin which is further converted to dihydrogeodin by the sulochrin halogenase gedL (PubMed:24009710).
Finally, the dihydrogeodin oxidase gedJ catalyzes the stereospecific phenol oxidative coupling reaction converting dihydrogeodin to geodin (PubMed:7665560).

Pathway

Secondary metabolite biosynthesis.

GO annotations

AspectTerm
Molecular Functionmonooxygenase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxidoreductase gedF
  • EC number
  • Alternative names
    • Geodin synthesis protein F

Gene names

    • Name
      gedF
    • ORF names
      ATEG_08455

Organism names

Accessions

  • Primary accession
    Q0CCX9

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000043706220-148Oxidoreductase gedF

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the avfA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    148
  • Mass (Da)
    16,150
  • Last updated
    2006-10-17 v1
  • Checksum
    96C51D98BF259C88
MPKLVLLSSATLDEQLSRATPALIRWILLRSASHVYRDLVETEAFLRAQGDWVSTVFIKPGGLSLDVQRGHALSLTEEKSPLSYADLAAAMIEAATDPDGRWDMRNVGVISVNGPAKSPPGAPMCIFMGFVRHYFPFLHPYLPSTGPG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH476605
EMBL· GenBank· DDBJ
EAU31628.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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