X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 38-428 ALONE AND IN COMPLEX WITH GALBETA1-3GALNAC, DISULFIDE BOND, ACTIVE SITE, REGION, GLYCOSYLATION AT ASN-58 AND ASN-95
Categories
PTM / Processing, Function, Family & Domains, Interaction, Structure
X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 38-428 IN COMPLEX WITH UDP-GLCNAC, DISULFIDE BOND, GLYCOSYLATION AT ASN-58 AND ASN-95, FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF CYS-217; ARG-378 AND LYS-401
we show that Gcnt1 transcription and subsequent P-lselectin ligand induction in Th1 cells is governed by binding of STAT4 and T-bet to a distal enhancer and further regulated by epigenetic marks such as H3K27me3.
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