Q09187 · MEL_SACPA

Function

Catalytic activity

  • Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.
    EC:3.2.1.22 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

147150100150200250300350400450
TypeIDPosition(s)Description
Binding site72substrate
Binding site73substrate
Binding site147substrate
Active site149Nucleophile
Binding site205substrate
Active site209Proton donor
Binding site251substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular region
Molecular Functionalpha-galactosidase activity
Biological Processglycoside catabolic process
Biological Processoligosaccharide metabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-galactosidase
  • EC number
  • Alternative names
    • Alpha-D-galactoside galactohydrolase
    • MELp
    • Melibiase

Gene names

    • Name
      MEL

Organism names

Accessions

  • Primary accession
    Q09187

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000000100819-471Alpha-galactosidase
Disulfide bond42↔74
Glycosylation43N-linked (GlcNAc...) asparagine
Glycosylation105N-linked (GlcNAc...) asparagine
Disulfide bond121↔151
Glycosylation175N-linked (GlcNAc...) asparagine
Disulfide bond221↔237
Disulfide bond223↔230
Glycosylation270N-linked (GlcNAc...) asparagine
Glycosylation370N-linked (GlcNAc...) asparagine
Glycosylation403N-linked (GlcNAc...) asparagine
Glycosylation417N-linked (GlcNAc...) asparagine
Glycosylation422N-linked (GlcNAc...) asparagine
Glycosylation454N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyl hydrolase 27 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    471
  • Mass (Da)
    52,768
  • Last updated
    1996-11-01 v1
  • Checksum
    D6E73ACF54C41B7A
MFNLNFFNYTCHCEWCFWVLPSYNGLGLTPQMGWDNWNTFACNVSEDLLLNTADRISDIGLKDLGYKYVILDDCWSSGRDEDGFLVADEQKFPNGMGHVADRLHNNSFLFGMYSSAGEYTCAGYPGSLGREEEDAQFFANNRVDYLKYDNCYNKGRFGTPESSHKRYKAMSDALNKTGRPIFYSLCNWGQDLTFYWGSDIANSWRMSGDITAEFSRPDSRCPCDGDEYDCKYAGYHCSIMNILNKAAPMGQNGGIGGWNDLDNLEVGVGNLTDDEEKTHFSMWAMVKSPLIIGADVNHLKASSYSIYSQSSVIAINQDPKGIPATRVWRYYVPQTDKYGQGEIQFWSGPLENGDQVIALLNGGMKARPMNATLEDIFFDSYQGSEELSTSWDIYDLWANRIDNATASAILENNKVTNNTLYNATKLSYKEGLLNGDSRLFGTKVGTISPDGIINTTVPAHGIALYRLRSSS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X95505
EMBL· GenBank· DDBJ
CAA64759.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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