Q09103 · DGK2_DROME
- ProteinEye-specific diacylglycerol kinase
- GenerdgA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1457 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Required for the maintenance of phospholipid turnover within the photoreceptor.
Catalytic activity
- a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent diacylglycerol kinase activity | |
Molecular Function | metal ion binding | |
Biological Process | diacylglycerol metabolic process | |
Biological Process | G protein-coupled opsin signaling pathway | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid phosphorylation | |
Biological Process | negative regulation of opsin-mediated signaling pathway | |
Biological Process | phosphatidic acid biosynthetic process | |
Biological Process | phosphatidylinositol biosynthetic process | |
Biological Process | photoreceptor cell maintenance | |
Biological Process | phototransduction | |
Biological Process | protein kinase C-activating G protein-coupled receptor signaling pathway | |
Biological Process | sensory perception of smell | |
Biological Process | sensory perception of sound | |
Biological Process | thermotaxis | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEye-specific diacylglycerol kinase
- EC number
- Short namesDAG kinase 2; DGK 2; Diglyceride kinase 2
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ09103
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Flies exhibit photoreceptor cells that degenerate within a week after eclosion.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000218474 | 1-1457 | Eye-specific diacylglycerol kinase | |||
Sequence: MQQQQQPSIDQLPEPTASTSNSATTKPTIATATTSTTTTSGNNFHQQLQATTAATMQRLRTTFTRSRTPTGAEMKMQNSLEVPKQVRSASFDEMQLESQRASSSLLKQQSSSSASADERSSEAGFLQVPLAAHQQRSHSFDSATASAGSDDSGTFLEVPRRLKARRSSSTKTPPPCIHCHYLEEYERRMTAEQRYFIDHRELTALSYSNTSSEASEDEDEVEGHNAEEEEEGSAAIEDAEEETTEAATEEADEDPRTEVESEHDHDPDDDAALEMDIRIGNMSQGSSIEESRARLPRQMRRHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLPPQPTTPCGITFTLSPTNGDYPSPPHLPLDPGSPPISPCSSNSGRLPALAPIISTPCSSADADDAGAAMGLPVRARRRSISRQEAIFVEPTGNSLENVSHEEVDNSNTKSSVDTADSLDEASTMATCGSPGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPTDEQARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQGEHYWKPTSASGDLCCLNEECIKSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPWNDSFGASKPSIDDGLMEVVGLTTYQLPMLQAGMHGTCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRGDVQVNPLEKMQLHILRVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFEESISYPKVSQDWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDELYILDHEAATMPQTPDQERSFAAFSQRQAQNERRQMDQAQGRGPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAILLAAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYNHRDIVKYIIASATRRLINMADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVAFNKNANEIATYLESKQGTQPVDGWLDD |
Proteomic databases
Expression
Structure
Family & Domains
Features
Showing features for compositional bias, region, zinc finger, domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-120 | Polar residues | ||||
Sequence: MQQQQQPSIDQLPEPTASTSNSATTKPTIATATTSTTTTSGNNFHQQLQATTAATMQRLRTTFTRSRTPTGAEMKMQNSLEVPKQVRSASFDEMQLESQRASSSLLKQQSSSSASADERS | ||||||
Region | 1-123 | Disordered | ||||
Sequence: MQQQQQPSIDQLPEPTASTSNSATTKPTIATATTSTTTTSGNNFHQQLQATTAATMQRLRTTFTRSRTPTGAEMKMQNSLEVPKQVRSASFDEMQLESQRASSSLLKQQSSSSASADERSSEA | ||||||
Compositional bias | 136-151 | Polar residues | ||||
Sequence: RSHSFDSATASAGSDD | ||||||
Region | 136-177 | Disordered | ||||
Sequence: RSHSFDSATASAGSDDSGTFLEVPRRLKARRSSSTKTPPPCI | ||||||
Region | 207-339 | Disordered | ||||
Sequence: YSNTSSEASEDEDEVEGHNAEEEEEGSAAIEDAEEETTEAATEEADEDPRTEVESEHDHDPDDDAALEMDIRIGNMSQGSSIEESRARLPRQMRRHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLPPQPTT | ||||||
Compositional bias | 213-257 | Acidic residues | ||||
Sequence: EASEDEDEVEGHNAEEEEEGSAAIEDAEEETTEAATEEADEDPRT | ||||||
Compositional bias | 258-275 | Basic and acidic residues | ||||
Sequence: EVESEHDHDPDDDAALEM | ||||||
Compositional bias | 301-339 | Polar residues | ||||
Sequence: RHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLPPQPTT | ||||||
Zinc finger | 591-641 | Phorbol-ester/DAG-type 1 | ||||
Sequence: HYWKPTSASGDLCCLNEECIKSGQRMKCSACQLVAHHNCIPFVNEKSTLAC | ||||||
Zinc finger | 661-724 | Phorbol-ester/DAG-type 2 | ||||
Sequence: HHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEEC | ||||||
Region | 758-799 | Disordered | ||||
Sequence: NNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRA | ||||||
Domain | 808-944 | DAGKc | ||||
Sequence: PEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGGYTDEPIGKILREIGMSQCVLMDRWRVKVTP | ||||||
Compositional bias | 1264-1292 | Polar residues | ||||
Sequence: TPDQERSFAAFSQRQAQNERRQMDQAQGR | ||||||
Region | 1264-1302 | Disordered | ||||
Sequence: TPDQERSFAAFSQRQAQNERRQMDQAQGRGPGSTDEDLQ | ||||||
Repeat | 1320-1349 | ANK 1 | ||||
Sequence: QTSDAILLAAQSGDLNMLRALHEQGYSLQS | ||||||
Repeat | 1353-1382 | ANK 2 | ||||
Sequence: NGQTALHFACKYNHRDIVKYIIASATRRLI | ||||||
Repeat | 1389-1418 | ANK 3 | ||||
Sequence: LGQTALHIAAEQNRRDICVMLVAAGAHLDT | ||||||
Repeat | 1422-1451 | ANK 4 | ||||
Sequence: GGNTPMMVAFNKNANEIATYLESKQGTQPV |
Sequence similarities
Belongs to the eukaryotic diacylglycerol kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q09103-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- Length1,457
- Mass (Da)160,142
- Last updated2005-06-21 v2
- Checksum8F4E33E9C1B665D1
Q09103-3
- NameB
- Differences from canonical
- 1-116: MQQQQQPSIDQLPEPTASTSNSATTKPTIATATTSTTTTSGNNFHQQLQATTAATMQRLRTTFTRSRTPTGAEMKMQNSLEVPKQVRSASFDEMQLESQRASSSLLKQQSSSSASA → MPERSISQRDLDEIEIESDEEEEELEQGVGLSTRSRRNRRGASDSPAASRARNATNGIQNRGRERERERERERSRERFGGTNAADEARFYDDEEQRMEDDGEEDSDEDIEMLDYDT
- 117-564: Missing
- 1315-1315: S → SNKDRLFSFNEDVFGCGFS
- 1445-1457: KQGTQPVDGWLDD → QERFMHLEKQTRI
Q09103-2
- NameC
- Differences from canonical
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6H2EFG8 | A0A6H2EFG8_DROME | rdgA | 1365 | ||
M9PH20 | M9PH20_DROME | rdgA | 1460 | ||
M9PHG3 | M9PHG3_DROME | rdgA | 1462 | ||
X2JE67 | X2JE67_DROME | rdgA | 1307 | ||
M9MSN3 | M9MSN3_DROME | rdgA | 1009 | ||
M9MS31 | M9MS31_DROME | rdgA | 1452 | ||
X2JEJ9 | X2JEJ9_DROME | rdgA | 1314 | ||
A0A023GPM5 | A0A023GPM5_DROME | rdgA | 991 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_030264 | 1-116 | in isoform B | |||
Sequence: MQQQQQPSIDQLPEPTASTSNSATTKPTIATATTSTTTTSGNNFHQQLQATTAATMQRLRTTFTRSRTPTGAEMKMQNSLEVPKQVRSASFDEMQLESQRASSSLLKQQSSSSASA → MPERSISQRDLDEIEIESDEEEEELEQGVGLSTRSRRNRRGASDSPAASRARNATNGIQNRGRERERERERERSRERFGGTNAADEARFYDDEEQRMEDDGEEDSDEDIEMLDYDT | ||||||
Compositional bias | 1-120 | Polar residues | ||||
Sequence: MQQQQQPSIDQLPEPTASTSNSATTKPTIATATTSTTTTSGNNFHQQLQATTAATMQRLRTTFTRSRTPTGAEMKMQNSLEVPKQVRSASFDEMQLESQRASSSLLKQQSSSSASADERS | ||||||
Alternative sequence | VSP_030265 | 1-132 | in isoform C | |||
Sequence: MQQQQQPSIDQLPEPTASTSNSATTKPTIATATTSTTTTSGNNFHQQLQATTAATMQRLRTTFTRSRTPTGAEMKMQNSLEVPKQVRSASFDEMQLESQRASSSLLKQQSSSSASADERSSEAGFLQVPLAA → MERLLHAVREEFQTEDEYETEVDDEGNVLHRSSISSCSSSSSSSNTSSSSDGSNSTASQPLSPSLPQPRRRLQRSDSFGSVGGGVAGGVAGSGATGAGGVRRFRRSSIGMQRKSAFRQRKLDSLGAWRRKRR | ||||||
Sequence conflict | 32 | in Ref. 1; BAA04135 | ||||
Sequence: A → V | ||||||
Alternative sequence | VSP_030266 | 117-564 | in isoform B | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_030267 | 133-565 | in isoform C | |||
Sequence: Missing | ||||||
Compositional bias | 136-151 | Polar residues | ||||
Sequence: RSHSFDSATASAGSDD | ||||||
Sequence conflict | 208 | in Ref. 1; BAA04135 | ||||
Sequence: S → T | ||||||
Compositional bias | 213-257 | Acidic residues | ||||
Sequence: EASEDEDEVEGHNAEEEEEGSAAIEDAEEETTEAATEEADEDPRT | ||||||
Compositional bias | 258-275 | Basic and acidic residues | ||||
Sequence: EVESEHDHDPDDDAALEM | ||||||
Compositional bias | 301-339 | Polar residues | ||||
Sequence: RHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLPPQPTT | ||||||
Sequence conflict | 438 | in Ref. 1; BAA04135 | ||||
Sequence: N → K | ||||||
Sequence conflict | 565 | in Ref. 1; BAA04135 | ||||
Sequence: R → RR | ||||||
Sequence conflict | 667 | in Ref. 1; BAA04135 | ||||
Sequence: K → N | ||||||
Sequence conflict | 679-684 | in Ref. 1; BAA04135 | ||||
Sequence: Missing | ||||||
Sequence conflict | 778 | in Ref. 1; BAA04135 | ||||
Sequence: G → GGG | ||||||
Sequence conflict | 924 | in Ref. 5; AAQ22428 | ||||
Sequence: L → M | ||||||
Sequence conflict | 983 | in Ref. 5; AAQ22428 | ||||
Sequence: E → G | ||||||
Sequence conflict | 1128 | in Ref. 5; AAQ22428 | ||||
Sequence: I → N | ||||||
Compositional bias | 1264-1292 | Polar residues | ||||
Sequence: TPDQERSFAAFSQRQAQNERRQMDQAQGR | ||||||
Alternative sequence | VSP_028732 | 1315 | in isoform B | |||
Sequence: S → SNKDRLFSFNEDVFGCGFS | ||||||
Alternative sequence | VSP_028733 | 1445-1457 | in isoform B | |||
Sequence: KQGTQPVDGWLDD → QERFMHLEKQTRI |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D17315 EMBL· GenBank· DDBJ | BAA04135.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014298 EMBL· GenBank· DDBJ | AAF46430.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | ABW09364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | ABW09365.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY075349 EMBL· GenBank· DDBJ | AAL68208.1 EMBL· GenBank· DDBJ | mRNA | ||
BT009959 EMBL· GenBank· DDBJ | AAQ22428.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |