Q08HI2 · Q08HI2_PHOHO

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Functioncytochrome-c oxidase activity
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 3

Gene names

    • Name
      COIII
    • Synonyms
      COX3

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q08HI2

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-34Helical
Transmembrane40-58Helical
Transmembrane79-102Helical
Transmembrane159-177Helical
Transmembrane197-220Helical
Transmembrane240-260Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-261Heme-copper oxidase subunit III family profile

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    261
  • Mass (Da)
    29,941
  • Last updated
    2006-10-31 v1
  • Checksum
    AC6BD63048F01C80
MTHQTHAYHMVNPSPWPLTGALSALLMTSGLIMWFHFNSIHLLLLGLMTNTLTMYQWWRDIVRESTFQGHHTPTVQKGLRYGMILFIVSEVFFFAGFFWAFYHSSLAPTPELGGCWPPAGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQALFITILLGLYFTLLQASEYYETPFTISDGVYGSTFFMATGFHGLHVIIGSTFLTVCFLRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue261

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX388143
EMBL· GenBank· DDBJ
ANN02974.1
EMBL· GenBank· DDBJ
Genomic DNA
AM181019
EMBL· GenBank· DDBJ
CAJ56916.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp