Q08ER8 · ZN543_HUMAN
- ProteinZinc finger protein 543
- GeneZNF543
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids600 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May be involved in transcriptional regulation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
The subsequence AASAQVSVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQLDHRQELWMATKDLSQSSYPG, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 543
Gene names
- Community suggested namesZNF543
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ08ER8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_032171 | 55 | in dbSNP:rs6510057 | |||
Sequence: P → A | ||||||
Natural variant | VAR_032172 | 107 | in dbSNP:rs8100491 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_032173 | 246 | in dbSNP:rs1968090 | |||
Sequence: L → H | ||||||
Natural variant | VAR_032174 | 287 | in dbSNP:rs35238720 | |||
Sequence: E → V | ||||||
Natural variant | VAR_032175 | 439 | in dbSNP:rs10411486 | |||
Sequence: V → D | ||||||
Natural variant | VAR_032176 | 573 | in dbSNP:rs10410649 | |||
Sequence: M → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 783 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000286809 | 1-600 | Zinc finger protein 543 | |||
Sequence: MAASAQVSVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQLDHRQELWMATKDLSQSSYPGDNTKPKTTEPTFSHLALPEEVLLQEQLTQGASKNSQLGQSKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSERDGLGSDDGVCTKITQKQVSTEGDLYECDSHGPVTDALIREEKNSYKCEECGKVFKKNALLVQHERIHTQVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEKPYECIECGKAFNRRSYLTWHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQRIHTGEKPYECSECGKAFTHCSTFVLHKRTHTGEKPYECKECGKAFSDRADLIRHFSIHTGEKPYECVECGKAFNRSSHLTRHQQIHTGEKPYECIQCGKAFCRSANLIRHSIIHTGEKPYECSECGKAFNRGSSLTHHQRIHTGRNPTIVTDVGRPFMTAQTSVNIQELLLGKEFLNITTEENLW |
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q08ER8 | KRTAP10-6 P60371 | 3 | EBI-10226133, EBI-12012928 | |
BINARY | Q08ER8 | KRTAP10-7 P60409 | 3 | EBI-10226133, EBI-10172290 | |
BINARY | Q08ER8 | MCC P23508 | 3 | EBI-10226133, EBI-307531 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-80 | KRAB | ||||
Sequence: VTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQLDHRQELWMATKDLSQSSYP | ||||||
Compositional bias | 110-126 | Polar residues | ||||
Sequence: QGASKNSQLGQSKDQDG | ||||||
Region | 110-131 | Disordered | ||||
Sequence: QGASKNSQLGQSKDQDGPSEMQ | ||||||
Zinc finger | 199-221 | C2H2-type 1 | ||||
Sequence: YKCEECGKVFKKNALLVQHERIH | ||||||
Zinc finger | 227-249 | C2H2-type 2 | ||||
Sequence: YECTECGKTFSKSTHLLQHLIIH | ||||||
Zinc finger | 255-277 | C2H2-type 3 | ||||
Sequence: YKCMECGKAFNRRSHLTRHQRIH | ||||||
Zinc finger | 283-305 | C2H2-type 4 | ||||
Sequence: YKCSECGKAFTHRSTFVLHHRSH | ||||||
Zinc finger | 311-333 | C2H2-type 5 | ||||
Sequence: FVCKECGKAFRDRPGFIRHYIIH | ||||||
Zinc finger | 339-361 | C2H2-type 6 | ||||
Sequence: YECIECGKAFNRRSYLTWHQQIH | ||||||
Zinc finger | 367-389 | C2H2-type 7 | ||||
Sequence: FECNECGKAFCESADLIQHYIIH | ||||||
Zinc finger | 395-417 | C2H2-type 8 | ||||
Sequence: YKCMECGKAFNRRSHLKQHQRIH | ||||||
Zinc finger | 423-445 | C2H2-type 9 | ||||
Sequence: YECSECGKAFTHCSTFVLHKRTH | ||||||
Zinc finger | 451-473 | C2H2-type 10 | ||||
Sequence: YECKECGKAFSDRADLIRHFSIH | ||||||
Zinc finger | 479-501 | C2H2-type 11 | ||||
Sequence: YECVECGKAFNRSSHLTRHQQIH | ||||||
Zinc finger | 507-529 | C2H2-type 12 | ||||
Sequence: YECIQCGKAFCRSANLIRHSIIH | ||||||
Zinc finger | 535-557 | C2H2-type 13 | ||||
Sequence: YECSECGKAFNRGSSLTHHQRIH |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length600
- Mass (Da)68,404
- Last updated2010-11-30 v3
- ChecksumEB79C2956B980DED
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 110-126 | Polar residues | ||||
Sequence: QGASKNSQLGQSKDQDG | ||||||
Sequence conflict | 470 | in Ref. 1; BAD18681 | ||||
Sequence: F → L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK131547 EMBL· GenBank· DDBJ | BAD18681.1 EMBL· GenBank· DDBJ | mRNA | ||
AC005261 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC101012 EMBL· GenBank· DDBJ | AAI01013.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101013 EMBL· GenBank· DDBJ | AAI01014.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101014 EMBL· GenBank· DDBJ | AAI01015.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101015 EMBL· GenBank· DDBJ | AAI01016.1 EMBL· GenBank· DDBJ | mRNA | ||
AL834534 EMBL· GenBank· DDBJ | CAD39190.1 EMBL· GenBank· DDBJ | mRNA |