Q08C83 · Q08C83_DANRE
- ProteinMitochondrial 2-oxodicarboxylate carrier
- Geneslc25a21
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids298 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.
Catalytic activity
- 2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)2-oxoadipate (in)CHEBI:57499
+ 2-oxoglutarate (out)CHEBI:16810= 2-oxoadipate (out)CHEBI:57499+ 2-oxoglutarate (in)CHEBI:16810 - 2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)
- L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)
- citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)
- glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)
- heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)
- hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Biological Process | transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitochondrial 2-oxodicarboxylate carrier
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ08C83
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 10-99 | Solcar | |||
Repeat | 106-195 | Solcar | |||
Repeat | 204-293 | Solcar | |||
Sequence similarities
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length298
- Mass (Da)32,998
- Last updated2006-10-31 v1
- Checksum13E92589737ACDFA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC124342 EMBL· GenBank· DDBJ | AAI24343.1 EMBL· GenBank· DDBJ | mRNA |