Q08BS8 · Q08BS8_DANRE
- ProteinHistone deacetylase
- Genehdac4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1023 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Catalytic activity
- H2O + N6-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]
Features
Showing features for binding site, active site, site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone deacetylase activity | |
Molecular Function | metal ion binding | |
Biological Process | embryonic cranial skeleton morphogenesis | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | neural crest cell migration | |
Biological Process | perichondral ossification | |
Biological Process | pronephros morphogenesis | |
Biological Process | regulation of neural crest formation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone deacetylase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ08BS8
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, coiled coil, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 33-122 | Histone deacetylase glutamine rich N-terminal | ||||
Sequence: DPAQREHQLQQELLALKQKQQIQRQLLIEEFQRQHEQLSRQHEAQLQEHVKHQQDLLALKHQQELLEHQRKLGRHRQEQEMEKQQREQKL | ||||||
Coiled coil | 60-128 | |||||
Sequence: IEEFQRQHEQLSRQHEAQLQEHVKHQQDLLALKHQQELLEHQRKLGRHRQEQEMEKQQREQKLQLLKNK | ||||||
Compositional bias | 175-195 | Polar residues | ||||
Sequence: KTQHSSLDQSSPPQTGISTYN | ||||||
Region | 175-287 | Disordered | ||||
Sequence: KTQHSSLDQSSPPQTGISTYNHPVLGMYDPKDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRKDGPITTAKKRSLDMAESACSSAPGSGPSSPNNSSNNITNENGIAGS | ||||||
Compositional bias | 205-248 | Basic and acidic residues | ||||
Sequence: KDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRKDGPITTA | ||||||
Compositional bias | 262-287 | Polar residues | ||||
Sequence: SAPGSGPSSPNNSSNNITNENGIAGS | ||||||
Region | 472-526 | Disordered | ||||
Sequence: KPSEPNRQHESHPEETEEELREHQGLGDPADPLPHGVTIKQEPPDEQDEDFQQRE | ||||||
Compositional bias | 474-499 | Basic and acidic residues | ||||
Sequence: SEPNRQHESHPEETEEELREHQGLGD | ||||||
Compositional bias | 512-526 | Basic and acidic residues | ||||
Sequence: QEPPDEQDEDFQQRE | ||||||
Domain | 620-931 | Histone deacetylase | ||||
Sequence: HPEHAGRIQSIWSRLQETGLRGQCECIRGRKATLEELQTVHSEAHVLLYGTNPLRQKLDSSVTPMFVRLPCGGIGVDSDTIWNEVHSSSAARLAVGSVVDLVFKVASGELRNGFAVVRPPGHHAEESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYSDPNVLYLSLHRYDDGNFFPGSGAPDEVGIGPGVGFNVNMAFTGGLEPPMGDADYLAAFRSVVMPIANEFSPDVVLVSSGFDAVEGHPPPLGGYKLTAKCFGYLTKQLMGLAGGRLVLALEGGHDLTAICDASEACVSAL | ||||||
Region | 1004-1023 | Disordered | ||||
Sequence: ANKHMGKRPEEEPMEEEPPL | ||||||
Compositional bias | 1007-1023 | Basic and acidic residues | ||||
Sequence: HMGKRPEEEPMEEEPPL |
Sequence similarities
Belongs to the histone deacetylase family. HD type 2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,023
- Mass (Da)113,241
- Last updated2006-10-31 v1
- Checksum1636BF7564839C8E
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0R4IAH0 | A0A0R4IAH0_DANRE | hdac4 | 1052 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 175-195 | Polar residues | ||||
Sequence: KTQHSSLDQSSPPQTGISTYN | ||||||
Compositional bias | 205-248 | Basic and acidic residues | ||||
Sequence: KDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRKDGPITTA | ||||||
Compositional bias | 262-287 | Polar residues | ||||
Sequence: SAPGSGPSSPNNSSNNITNENGIAGS | ||||||
Compositional bias | 474-499 | Basic and acidic residues | ||||
Sequence: SEPNRQHESHPEETEEELREHQGLGD | ||||||
Compositional bias | 512-526 | Basic and acidic residues | ||||
Sequence: QEPPDEQDEDFQQRE | ||||||
Compositional bias | 1007-1023 | Basic and acidic residues | ||||
Sequence: HMGKRPEEEPMEEEPPL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC124583 EMBL· GenBank· DDBJ | AAI24584.1 EMBL· GenBank· DDBJ | mRNA | ||
BC165681 EMBL· GenBank· DDBJ | AAI65681.1 EMBL· GenBank· DDBJ | mRNA |