Q08BS8 · Q08BS8_DANRE

Function

function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activity

Features

Showing features for binding site, active site, site.

110231002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site612Zn2+ (UniProtKB | ChEBI)
Binding site614Zn2+ (UniProtKB | ChEBI)
Binding site620Zn2+ (UniProtKB | ChEBI)
Binding site690Zn2+ (UniProtKB | ChEBI)
Active site742
Site915Contributes to catalysis

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionhistone deacetylase activity
Molecular Functionmetal ion binding
Biological Processembryonic cranial skeleton morphogenesis
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneural crest cell migration
Biological Processperichondral ossification
Biological Processpronephros morphogenesis
Biological Processregulation of neural crest formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase
  • EC number

Gene names

    • Name
      hdac4
    • Synonyms
      wu:fa96d08
      , wu:fc56f08
      , zgc:152701

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q08BS8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, coiled coil, compositional bias, region.

TypeIDPosition(s)Description
Domain33-122Histone deacetylase glutamine rich N-terminal
Coiled coil60-128
Compositional bias175-195Polar residues
Region175-287Disordered
Compositional bias205-248Basic and acidic residues
Compositional bias262-287Polar residues
Region472-526Disordered
Compositional bias474-499Basic and acidic residues
Compositional bias512-526Basic and acidic residues
Domain620-931Histone deacetylase
Region1004-1023Disordered
Compositional bias1007-1023Basic and acidic residues

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,023
  • Mass (Da)
    113,241
  • Last updated
    2006-10-31 v1
  • Checksum
    1636BF7564839C8E
MVDVSVALPLQVPPSAIPMDLRVDHQFALAPTDPAQREHQLQQELLALKQKQQIQRQLLIEEFQRQHEQLSRQHEAQLQEHVKHQQDLLALKHQQELLEHQRKLGRHRQEQEMEKQQREQKLQLLKNKERGQESAVASTEVKMRLQEFVLNKKKALAQRSLNHCLPSDPRYWYGKTQHSSLDQSSPPQTGISTYNHPVLGMYDPKDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRKDGPITTAKKRSLDMAESACSSAPGSGPSSPNNSSNNITNENGIAGSISNSAVEPSLAHRLTGREGPVSQLSLYTSPSLPNITLGLPATGPSSVASGQQDGDRMAVPGLQPGIPITTPFMPGAHLPSYLAASSLERESGSAHNTLLQHMVLLEQSAAQNSLVAGLSGVPLQSHSIHKLRQHRPLGRTQSAPLPQNSQALQQLVVQQQHQQFLEKHKQQFQQQQLHISKMMVKPSEPNRQHESHPEETEEELREHQGLGDPADPLPHGVTIKQEPPDEQDEDFQQRERQAEEELLFRQQALLLEQQRIHQLRNYQASMEAAGLSVSFPVHRPLSRAQSSPASATFPIVVQEPPAKPRFTTGLVYDTLMQKHQCMCGNSNIHPEHAGRIQSIWSRLQETGLRGQCECIRGRKATLEELQTVHSEAHVLLYGTNPLRQKLDSSVTPMFVRLPCGGIGVDSDTIWNEVHSSSAARLAVGSVVDLVFKVASGELRNGFAVVRPPGHHAEESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYSDPNVLYLSLHRYDDGNFFPGSGAPDEVGIGPGVGFNVNMAFTGGLEPPMGDADYLAAFRSVVMPIANEFSPDVVLVSSGFDAVEGHPPPLGGYKLTAKCFGYLTKQLMGLAGGRLVLALEGGHDLTAICDASEACVSALLGNELDPIPEDILQQRPNANAIQSMEKVLEVQSKYWRSLQRSVSTLGYSLREAQRCENEEAETVTAMASLSVANKHMGKRPEEEPMEEEPPL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0R4IAH0A0A0R4IAH0_DANREhdac41052

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias175-195Polar residues
Compositional bias205-248Basic and acidic residues
Compositional bias262-287Polar residues
Compositional bias474-499Basic and acidic residues
Compositional bias512-526Basic and acidic residues
Compositional bias1007-1023Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC124583
EMBL· GenBank· DDBJ
AAI24584.1
EMBL· GenBank· DDBJ
mRNA
BC165681
EMBL· GenBank· DDBJ
AAI65681.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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