Q08715 · URE23_HELFE

  • Protein
    Urease subunit alpha
  • Gene
    ureA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Caution

The orthologous protein is known as the gamma/beta subunit (UreAB) in most other bacteria.

Catalytic activity

Pathway

Nitrogen metabolism; urea degradation; CO2 and NH3 from urea (urease route): step 1/1.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenturease complex
Molecular Functionnickel cation binding
Molecular Functionurease activity
Biological Processurea catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urease subunit alpha
  • EC number
  • Alternative names
    • Urea amidohydrolase subunit alpha

Gene names

    • Name
      ureA

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Bacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter

Accessions

  • Primary accession
    Q08715

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000980701-237Urease subunit alpha

Interaction

Subunit

Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-102Urease gamma
Region103-237Urease beta

Sequence similarities

In the N-terminal section; belongs to the urease gamma subunit family.
In the C-terminal section; belongs to the urease beta subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    237
  • Mass (Da)
    26,091
  • Last updated
    1994-10-01 v1
  • Checksum
    289AF3127872F037
MKLTPKELDKLMLHYAGRLAEEALARGVKLNYTEAVALISGRVMEKARDGNKSVADLMQEGRTWLKKENVMDGVASMIHEVGIEANFPDGTKLVTIHTPVEDNGKLAPGEVFLKNEDITINAGKEAISLKVKNKGDRPVQVGSHFHFFEVNKLLDFDRAKSFCKRLDIASGTAVRFEPGEEKSVELIDIGGNKRIYGFNSLVDRQADADGKKLGLKRAKEKGFGSVNCGCEATKDKQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X69080
EMBL· GenBank· DDBJ
CAA48825.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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