Q08463 · FZD1_RAT

Function

function

Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6 or WNT7A. Contradictory results have been reported for activation by WNT7B. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).
A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)

Caution

Activation by specific Wnt family members may depend on the cells used for the experiment. Contradictory results have been reported for activation by WNT7B in human and mouse.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentplasma membrane
Molecular Functionfrizzled binding
Molecular FunctionG protein-coupled receptor activity
Molecular Functionidentical protein binding
Molecular FunctionPDZ domain binding
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein homodimerization activity
Molecular Functionsignaling receptor binding
Molecular FunctionWnt receptor activity
Molecular FunctionWnt-protein binding
Biological Processautocrine signaling
Biological Processcanonical Wnt signaling pathway
Biological Processcanonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
Biological Processcell-cell signaling
Biological Processcellular response to growth factor stimulus
Biological Processcellular response to peptide hormone stimulus
Biological Processcellular response to vitamin D
Biological Processendothelial cell differentiation
Biological Processhard palate development
Biological Processlung alveolus development
Biological Processmembranous septum morphogenesis
Biological Processmuscular septum morphogenesis
Biological Processnegative regulation of BMP signaling pathway
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Biological Processnon-canonical Wnt signaling pathway
Biological Processoutflow tract morphogenesis
Biological Processplanar cell polarity pathway involved in neural tube closure
Biological Processpositive regulation of DNA-binding transcription factor activity
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of neuron projection development
Biological Processpositive regulation of osteoblast differentiation
Biological Processpositive regulation of protein phosphorylation
Biological Processregulation of mesenchymal stem cell differentiation
Biological Processregulation of osteoblast differentiation
Biological Processregulation of presynapse assembly
Biological Processresponse to xenobiotic stimulus
Biological Processventricular septum morphogenesis
Biological ProcessWnt signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Frizzled-1
  • Short names
    Fz-1; rFz1

Gene names

    • Name
      Fzd1

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q08463

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain69-316Extracellular
Transmembrane317-337Helical; Name=1
Topological domain338-348Cytoplasmic
Transmembrane349-369Helical; Name=2
Topological domain370-396Extracellular
Transmembrane397-417Helical; Name=3
Topological domain418-439Cytoplasmic
Transmembrane440-460Helical; Name=4
Topological domain461-483Extracellular
Transmembrane484-504Helical; Name=5
Topological domain505-530Cytoplasmic
Transmembrane531-551Helical; Name=6
Topological domain552-595Extracellular
Transmembrane596-616Helical; Name=7
Topological domain617-641Cytoplasmic

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-68
ChainPRO_000001297569-641Frizzled-1
Disulfide bond111↔172
Disulfide bond119↔165
Glycosylation125N-linked (GlcNAc...) asparagine
Disulfide bond156↔192
Disulfide bond182↔221
Disulfide bond186↔209
Glycosylation225N-linked (GlcNAc...) asparagine

Post-translational modification

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed. Most abundant in kidney, liver, uterus, ovary and heart. Lower levels seen in brain and intestine. Extremely low in calvaria, mammary glands and testis.

Developmental stage

Expressed predominantly in neonatal tissues, at lower levels in adult.

Interaction

Subunit

Interacts with MYOC (By similarity).
Interacts with WNT7B (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q08463Fzd1 Q084634EBI-8766455, EBI-8766455
BINARY Q08463Fzd2 Q084646EBI-8766455, EBI-7402050

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, motif.

TypeIDPosition(s)Description
Region74-99Disordered
Domain106-224FZ
Motif619-624Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Motif639-641PDZ-binding

Domain

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
The FZ domain is involved in binding with Wnt ligands.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    641
  • Mass (Da)
    71,027
  • Last updated
    1996-11-01 v1
  • Checksum
    D82E2C113E81B8B6
MAEEAVPSESRAAGRPSLELCAVALPGRREEVGHQDTAGHRRPRAHSRCWARGLLLLLWLLEAPLLLGVRAQPAGQVSGPGQQRPPPPQPQQGGQQYNGERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERAQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6ACQ8A0A8I6ACQ8_RATFzd1555

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L02529
EMBL· GenBank· DDBJ
AAA41173.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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