Q08446 · SGT1_YEAST

Function

function

Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Required for both entry into S phase and kinetochore function. Also involved in cyclic AMP (cAMP) pathway, possibly by participating in the assembly or the conformational activation of specific multiprotein complexes.

Miscellaneous

Present with 1340 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentubiquitin ligase complex
Molecular Functionprotein-folding chaperone binding
Molecular Functionprotein-macromolecule adaptor activity
Biological Processkinetochore assembly
Biological Processprotein quality control for misfolded or incompletely synthesized proteins
Biological Processprotein-containing complex assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein SGT1
  • Alternative names
    • Suppressor of G2 allele of SKP1

Gene names

    • Name
      SGT1
    • ORF names
      YOR29-08
    • Ordered locus names
      YOR057W

Organism names

Accessions

  • Primary accession
    Q08446
  • Secondary accessions
    • D6W2C0
    • E9P8U7

Proteomes

Organism-specific databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis31In sgt1-3; induces arrest of cell division in G2/M; when associated with L-99 and I-213.
Mutagenesis99In sgt1-3; induces arrest of cell division in G2/M; when associated with P-31 I-213.
Mutagenesis213In sgt1-3; induces arrest of cell division in G2/M; when associated with P-31 and L-99.
Mutagenesis220In sgt1-5; induces arrest of cell division in G2/M; when associated with K-364.
Mutagenesis364In sgt1-5; induces arrest of cell division in G2/M; when associated with V-220.
Mutagenesis371In A364a; suppressor of the cdc35-1 allele.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 12 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, cross-link, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001853931-395Protein SGT1
Cross-link32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue168Phosphoserine
Modified residue171Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with SKP1/CBF3D. Part of SCF E3 ubiquitin ligase complexes containing SKP1, CDC53, HRT1 and some F-box proteins. Interacts with CIR1/CDC35.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q08446CTF13 P352033EBI-17070, EBI-4085
BINARY Q08446HSP82 P028292EBI-17070, EBI-8659
BINARY Q08446SKP1 P522868EBI-17070, EBI-4090

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias137-156Basic and acidic residues
Region137-175Disordered
Compositional bias157-175Polar residues
Domain182-277CS
Domain312-395SGS
Region373-395Disordered

Sequence similarities

Belongs to the SGT1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    395
  • Mass (Da)
    44,860
  • Last updated
    1996-11-01 v1
  • Checksum
    5DE65874BE155552
MPVEKDLKTAYKALYDEKEPLKALHLYDEILKGSPTNLTALIFKAACLEKLYFGFSDWHSDATMENAKELLDKALMTAEGRGDRSKIGLVNFRYFVHFFNIKDYELAQSYFKKAKNLGYVDDTLPLWEDRLETKLNKKNKKQKDSTNKHTIKPVESIENRGDNNSSHSPISPLKIETAPQESPKFKIDWYQSSTSVTISLFTVNLPESKEQVNIYISPNDRRTLSISYQVPKSGSEFQYNAKLSHEVDPKAVSLKIFPKKLEITLSKIDSTQWKKLEEDILTESSRLSDEGKNSDSATRLLSAETASKERLSYPSSSKKKIDWSKLDIDEEADEEAGSADSFFQKLYAGADPDTKRAMMKSFIESNGTALSTDWEDVSKGTVKTSPPEGMEPKHW

Features

Showing features for sequence conflict, compositional bias.

Type
IDPosition(s)Description
Sequence conflict13in Ref. 4; AAS56369
Compositional bias137-156Basic and acidic residues
Compositional bias157-175Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U88830
EMBL· GenBank· DDBJ
AAB48841.1
EMBL· GenBank· DDBJ
Genomic DNA
Z70678
EMBL· GenBank· DDBJ
CAA94542.1
EMBL· GenBank· DDBJ
Genomic DNA
Z74965
EMBL· GenBank· DDBJ
CAA99250.1
EMBL· GenBank· DDBJ
Genomic DNA
AY558043
EMBL· GenBank· DDBJ
AAS56369.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006948
EMBL· GenBank· DDBJ
DAA10836.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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