Q08417 · RSB1_YEAST
- ProteinSphingoid long-chain base transporter RSB1
- GeneRSB1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids382 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell periphery | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | fungal-type vacuole | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | long-chain fatty acid transmembrane transporter activity | |
Biological Process | phospholipid translocation | |
Biological Process | sphingoid long-chain base transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Chemistry
Names & Taxonomy
Protein names
- Recommended nameSphingoid long-chain base transporter RSB1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ08417
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-34 | Extracellular | |||
Transmembrane | 35-55 | Helical | |||
Topological domain | 56-57 | Cytoplasmic | |||
Transmembrane | 58-78 | Helical | |||
Topological domain | 79-90 | Extracellular | |||
Transmembrane | 91-111 | Helical | |||
Topological domain | 112-135 | Cytoplasmic | |||
Transmembrane | 136-156 | Helical | |||
Topological domain | 157-171 | Extracellular | |||
Transmembrane | 172-192 | Helical | |||
Topological domain | 193-241 | Cytoplasmic | |||
Transmembrane | 242-262 | Helical | |||
Topological domain | 263-281 | Extracellular | |||
Transmembrane | 282-302 | Helical | |||
Topological domain | 303-382 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 3 | Increases sensitivity towards LCBs. | |||
Mutagenesis | 6 | Increases sensitivity towards LCBs. | |||
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000262738 | 1-382 | Sphingoid long-chain base transporter RSB1 | ||
Glycosylation | 3 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 6 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Induction
In response to loss of mitochondrial DNA in a transcription factor PDR3-dependent manner. Induced in response to altered glycerophospholipid asymmetry of the plasma membrane in a transcription factor PDR1-dependent manner.
Structure
Family & Domains
Sequence similarities
Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length382
- Mass (Da)43,187
- Last updated2010-03-23 v3
- Checksum3D49E28D16CC5908
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z74957 EMBL· GenBank· DDBJ | CAA99241.1 EMBL· GenBank· DDBJ | Genomic DNA | Frameshift | |
BK006948 EMBL· GenBank· DDBJ | DAA10831.1 EMBL· GenBank· DDBJ | Genomic DNA | Frameshift |