Q08116 · RGS1_HUMAN

  • Protein
    Regulator of G-protein signaling 1
  • Gene
    RGS1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894).
Inhibits B cell chemotaxis toward CXCL12 (By similarity).
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic side of plasma membrane
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular Functioncalmodulin binding
Molecular FunctionG-protein alpha-subunit binding
Molecular FunctionGTPase activator activity
Molecular FunctionGTPase activity
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processimmune response
Biological Processleukotriene signaling pathway
Biological Processnegative regulation of signal transduction
Biological Processpositive regulation of GTPase activity
Biological Processresponse to bacterium
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Regulator of G-protein signaling 1
  • Short names
    RGS1
  • Alternative names
    • B-cell activation protein BL34
    • Early response protein 1R20

Gene names

    • Name
      RGS1
    • Synonyms
      1R20, BL34, IER1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q08116
  • Secondary accessions
    • B2RDM9
    • B4DZY0
    • Q07918
    • Q9H1W2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 262 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002041751-209Regulator of G-protein signaling 1

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in peripheral blood monocytes (PubMed:10480894).
Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).

Induction

In response to several B-cell activation signals.

Gene expression databases

    • ENSG00000090104Expressed in C1 segment of cervical spinal cord and 173 other cell types or tissues

Organism-specific databases

Interaction

Subunit

Interacts with GNAI1 and GNAQ.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain85-200RGS

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q08116-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    209
  • Mass (Da)
    23,858
  • Last updated
    2009-03-24 v3
  • Checksum
    D8D7D8E80819496A
MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK

Q08116-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 149-209: INIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK → VSIKLIIISFSIKDPICRNNI

Sequence caution

The sequence AAB26289.1 differs from that shown. Reason: Erroneous initiation
The sequence AAH15510.1 differs from that shown. Reason: Erroneous initiation
The sequence BAG37976.1 differs from that shown. Reason: Erroneous initiation
The sequence BAG64242.1 differs from that shown. Reason: Erroneous initiation
The sequence CAA51826.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_036422149-209in isoform 2
Sequence conflict177in Ref. 1; BAG37976
Sequence conflict194in Ref. 5; CAA51826

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK303138
EMBL· GenBank· DDBJ
BAG64242.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK315607
EMBL· GenBank· DDBJ
BAG37976.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AL136987
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC015510
EMBL· GenBank· DDBJ
AAH15510.1
EMBL· GenBank· DDBJ
mRNA Different initiation
S59049
EMBL· GenBank· DDBJ
AAB26289.1
EMBL· GenBank· DDBJ
mRNA Different initiation
X73427
EMBL· GenBank· DDBJ
CAA51826.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AF493925
EMBL· GenBank· DDBJ
AAM12639.1
EMBL· GenBank· DDBJ
mRNA
BT006668
EMBL· GenBank· DDBJ
AAP35314.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp