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Q07VC7 · SECA1_RHOP5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: May bind 1 zinc ion per subunit.

Features

Showing features for binding site.

1947100200300400500600700800900
TypeIDPosition(s)Description
Binding site87ATP (UniProtKB | ChEBI)
Binding site105-109ATP (UniProtKB | ChEBI)
Binding site525ATP (UniProtKB | ChEBI)
Binding site931Zn2+ (UniProtKB | ChEBI)
Binding site933Zn2+ (UniProtKB | ChEBI)
Binding site942Zn2+ (UniProtKB | ChEBI)
Binding site943Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionprotein-exporting ATPase activity
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA 1
  • EC number

Gene names

    • Name
      secA1
    • Ordered locus names
      RPE_0146

Organism names

Accessions

  • Primary accession
    Q07VC7

Subcellular Location

Cell inner membrane
; Peripheral membrane protein
Cytoplasm
Note: Distribution is 50-50.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003209691-947Protein translocase subunit SecA 1

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region907-937Disordered
Compositional bias908-937Basic and acidic residues

Sequence similarities

Belongs to the SecA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    947
  • Mass (Da)
    106,445
  • Last updated
    2006-10-31 v1
  • MD5 Checksum
    89E40F997C36B873C715483FE8A867E0
MIGALARRLFGSPNDRRIKGYQPRVAAINALEPEVAALSDEALRARTVDFRAQIAAGATLDDILVPAFATVREAAKRTLGQRHFDVQLIGGMVLHEGDIAEMKTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLAKRDSAWMGEIYTFLGMTTGVIVHGLSDAERKAAYGCDITYGTNNEYGFDYLRDNMKYTLEEMVQRGHAYAIVDEVDSILIDEARTPLIISGPLDDRSEFYNTIDTFLPKLDKATDFEVDEKQRTVTLTEVGMETIEVLLRDAGQLKGESLYDIENVSVVHHINQALRAHSLFQRDKDYIVRNDEVIIIDEFTGRMMPGRRYSEGLHQALEAKEHVTVQPENQTLASITFQNYFRMYDKLAGMTGTALTEADELFDIYKLEVVEIPTNVPIARLDEDDEVYRTQNEKYAAILAEVERANSRLQPVLVGTASIEKSEVLADYLKNNGYKQIDFADPKGMEKLYAAARAGKPAKLFAVLNARFHEQEAYIVAEAGVPGAITIATNMAGRGTDIKLGGSLEMRIEHETVDITDEAEKAAKIELIKADVERFRELVLRAEETIEIEPAKGAKPAKTLTRPGGLYIIGSERHESRRIDNQLRGRSGRQGDPGRSKFFLSLEDDLMRIFGSDRLDTMLTKLGLKEGEAIIHPWINKALEKAQQKVEARNFDIRKNLLKFDNVSNDQRKVIFDQRIDLMQDESVAETVSDMRHIFVEDLVAKHVPEHAYAEQWDVAGLKEELNRVLGLDLPVEEWAKEEGIAEEELLSRIENRADEHMAAKVAQWGPEMMRYAEKSILLQTLDHLWREHLVMLDHLRNVIGLRGYGQRDPLQEYKSEAFNLFEALIAHLREAVTAQLMRVEIVTQEPQPELPPMAAHKFDPQTGEDELAFASVALAPADDADKAARDPNRPETWGKVGRNEDCPCNSGKKYKHCHGRYA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias908-937Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000463
EMBL· GenBank· DDBJ
ABJ04107.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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