Q07UG8 · Q07UG8_RHOP5

Function

function

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functiondihydrofolate synthase activity
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processfolic acid biosynthetic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate synthase/folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
    • Folylpolyglutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • Ordered locus names
      RPE_0457

Organism names

Accessions

  • Primary accession
    Q07UG8

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-274Mur ligase central
Domain315-431Mur ligase C-terminal

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    447
  • Mass (Da)
    47,209
  • Last updated
    2006-10-31 v1
  • MD5 Checksum
    1247966B7FC63AEC07F15A5FA988DBB5
MSEGAAVPETPLAELRARLARLHPKAIDLSLDRMRRLLAQLGDPQLRLAPVIHVAGTNGKGSTLAYLRAILEAAGLAVHAYTSPWLVRPNESFRIGHQGGGVLVGDDELIAALSHCEQANAGAPITLFEIETAAAFCLFARHPADVVLLEVGLGGRLDSTNVIEQPLASVIAPIGIDHTEFLGATLEAIATEKAGIIKRGVPVITAEQPDEAMAAIERQARRCHAPLSAAGQHWHVSIDRGRLVYQDERGLLDLAAPRLFGRHQFDNAGLAIATLRAIEHFSIDNTAYEAGVAGAQWPARMQRLAAGLLVDAAPRGSELWLDGGHNADGGRVAAAALGDLEERVSRPLVVIAGMMANKDAAAFLANFAGLTRHIIAVPIPTRAAAMPPEQLADAARKLGMRVEIAASVEAALQSVSRLLYEVPPRILIAGSLYLAGHVLAVNGTSPV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000463
EMBL· GenBank· DDBJ
ABJ04416.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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