Q07I86 · RNH2_RHOP5

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphomonoester.
    EC:3.1.26.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

Features

Showing features for binding site.

127820406080100120140160180200220240260
TypeIDPosition(s)Description
Binding site77a divalent metal cation (UniProtKB | ChEBI)
Binding site78a divalent metal cation (UniProtKB | ChEBI)
Binding site168a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribonuclease H2 complex
Molecular Functionmanganese ion binding
Molecular FunctionRNA binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication, removal of RNA primer
Biological Processmismatch repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease HII
  • EC number
  • Short names
    RNase HII

Gene names

    • Name
      rnhB
    • Ordered locus names
      RPE_4424

Organism names

Accessions

  • Primary accession
    Q07I86

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000311901-278Ribonuclease HII

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain71-259RNase H type-2

Sequence similarities

Belongs to the RNase HII family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    278
  • Mass (Da)
    29,675
  • Last updated
    2006-10-31 v1
  • Checksum
    EE6F06BA1DDD3917
MPHRARDTVLEPPELRARREFPVAWAGAGPQHPGMIRKAPKSDAAPPAKGVIAVAPPSFRRERALLKRGIWPVAGCDEAGRGPLAGPVVAAAVVLDPKRIPKGLDDSKKLTAEKREALFEEICATASFAVAYASPARIERDNILRASLWALARAVQALPEPPKHVFVDGRDKIITPCDCDAVIGGDALVLSIAAASIIAKVARDRLMCRLAEDCPGYGFDHHKGYGVPEHLAALDRLGPTKHHRKLFAPVAAAWDKHAPGERETAAAPPDLFGLSASA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000463
EMBL· GenBank· DDBJ
ABJ08348.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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