Q07982 · GFO_ZYMMO
- ProteinGlucose--fructose oxidoreductase
- Genegfo
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids433 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol
Cofactor
Note: Binds 1 NADP+ per subunit. The NADP+ cannot dissociate.
Pathway
Carbohydrate metabolism; D-sorbitol biosynthesis; D-sorbitol from D-fructose and D-glucose: step 1/1.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | periplasmic space | |
Molecular Function | glucose-fructose oxidoreductase activity | |
Molecular Function | nucleotide binding | |
Biological Process | sorbitol biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose--fructose oxidoreductase
- EC number
- Short namesGFOR
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Zymomonadaceae > Zymomonas
Accessions
- Primary accessionQ07982
- Secondary accessions
Proteomes
Subcellular Location
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-52 | Tat-type signal | ||||
Sequence: MTNKISSSDNLSNAVSATDDNASRTPNLTRRALVGGGVGLAAAGALASGLQA | ||||||
Chain | PRO_0000010851 | 53-433 | Glucose--fructose oxidoreductase | |||
Sequence: ATLPAGASQVPTTPAGRPMPYAIRPMPEDRRFGYAIVGLGKYALNQILPGFAGCQHSRIEALVSGNAEKAKIVAAEYGVDPRKIYDYSNFDKIAKDPKIDAVYIILPNSLHAEFAIRAFKAGKHVMCEKPMATSVADCQRMIDAAKAANKKLMIGYRCHYDPMNRAAVKLIRENQLGKLGMVTTDNSDVMDQNDPAQQWRLRRELAGGGSLMDIGIYGLNGTRYLLGEEPIEVRAYTYSDPNDERFVEVEDRIIWQMRFRSGALSHGASSYSTTTTSRFSVQGDKAVLLMDPATGYYQNLISVQTPGHANQSMMPQFIMPANNQFSAQLDHLAEAVINNKPVRSPGEEGMQDVRLIQAIYEAARTGRPVNTDWGYVRQGGY |
Post-translational modification
Predicted to be exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven.
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-24 | Disordered | ||||
Sequence: MTNKISSSDNLSNAVSATDDNASR |
Sequence similarities
Belongs to the Gfo/Idh/MocA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length433
- Mass (Da)47,190
- Last updated2005-02-15 v2
- Checksum13CFADE84794E736
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 29 | in Ref. 1 and 4 | ||||
Sequence: T → N | ||||||
Sequence conflict | 43 | in Ref. 1 and 4 | ||||
Sequence: A → R | ||||||
Sequence conflict | 61 | in Ref. 1; AAA27690 and 4; CAA51534 | ||||
Sequence: Q → L | ||||||
Sequence conflict | 111-119 | in Ref. 1; AAA27690 | ||||
Sequence: IEALVSGNA → MKLWSAVT | ||||||
Sequence conflict | 170 | in Ref. 1; AAA27690 | ||||
Sequence: A → S | ||||||
Sequence conflict | 247-258 | in Ref. 1; AAA27690 | ||||
Sequence: PAQQWRLRRELA → LHSSGVCVVNS | ||||||
Sequence conflict | 420 | in Ref. 1; AAA27690 | ||||
Sequence: P → A | ||||||
Sequence conflict | 431-433 | in Ref. 1; AAA27690 | ||||
Sequence: GGY → VVIDSDLTYLG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M97379 EMBL· GenBank· DDBJ | AAA27690.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z80356 EMBL· GenBank· DDBJ | CAB02496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE008692 EMBL· GenBank· DDBJ | AAV89313.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X73088 EMBL· GenBank· DDBJ | CAA51534.1 EMBL· GenBank· DDBJ | Genomic DNA |