Q07904 · THI73_YEAST
- ProteinThiamine pathway transporter THI73
- GeneTHI73
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids523 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell periphery | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | transmembrane transporter activity | |
Biological Process | transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameThiamine pathway transporter THI73
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ07904
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-79 | Cytoplasmic | ||||
Sequence: MKNMSQRSMDVEKKAANADSCSVSTSSINVDDADVALRFLKQNGLDESSTANEDDVVAGEEANFYGSHELSPKVLRKVD | ||||||
Transmembrane | 80-100 | Helical | ||||
Sequence: LFILPFLCCTYLLMFLDKALL | ||||||
Topological domain | 101-118 | Extracellular | ||||
Sequence: NYAASMGIKDHLKGNEFS | ||||||
Transmembrane | 119-139 | Helical | ||||
Sequence: NLGTIFSAAYIFMEPVVTYLI | ||||||
Topological domain | 140-141 | Cytoplasmic | ||||
Sequence: QK | ||||||
Transmembrane | 142-162 | Helical | ||||
Sequence: FPISKILGTFITVWGIVLACH | ||||||
Topological domain | 163-176 | Extracellular | ||||
Sequence: AACKTYASLMVVRT | ||||||
Transmembrane | 177-197 | Helical | ||||
Sequence: LLGLFESSSAVGCIAISGMYY | ||||||
Topological domain | 198-207 | Cytoplasmic | ||||
Sequence: TKSEQSARIG | ||||||
Transmembrane | 208-228 | Helical | ||||
Sequence: FWATQAGTGYIVGGLISFGFL | ||||||
Topological domain | 229-239 | Extracellular | ||||
Sequence: HYHGTAFTSWQ | ||||||
Transmembrane | 240-260 | Helical | ||||
Sequence: IMFLVVGLVTVAFGVLTFLYL | ||||||
Topological domain | 261-312 | Cytoplasmic | ||||
Sequence: PDNVTNAWFLNKEEKIQVVEHIRANQTGLETKKFKKQQVKELFLHDKFTWPM | ||||||
Transmembrane | 313-333 | Helical | ||||
Sequence: LLLTACSQISTGAIGTFSVTI | ||||||
Topological domain | 334-345 | Extracellular | ||||
Sequence: TGTFGFDKYETA | ||||||
Transmembrane | 346-366 | Helical | ||||
Sequence: LLQLPIGAITAMIILITTQML | ||||||
Topological domain | 367-371 | Cytoplasmic | ||||
Sequence: SRWGH | ||||||
Transmembrane | 372-392 | Helical | ||||
Sequence: ITLITTSMYIPAIIGCIVLIS | ||||||
Topological domain | 393-400 | Extracellular | ||||
Sequence: LPLSHKIG | ||||||
Transmembrane | 401-421 | Helical | ||||
Sequence: NLFSLYLLYSGSCVITNIYIW | ||||||
Topological domain | 422-432 | Cytoplasmic | ||||
Sequence: NSCNTSGYTKR | ||||||
Transmembrane | 433-452 | Helical | ||||
Sequence: VFRNAITMIVYNVSCIIAPQ | ||||||
Topological domain | 453-466 | Extracellular | ||||
Sequence: MFRAYSAPRYIPAK | ||||||
Transmembrane | 467-487 | Helical | ||||
Sequence: IALLVTQCVCVPLQLYIGYIC | ||||||
Topological domain | 488-523 | Cytoplasmic | ||||
Sequence: KKENEKRDKEQEGQERKKYQFLDLTDIENRNFRYIY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000247182 | 1-523 | Thiamine pathway transporter THI73 | |||
Sequence: MKNMSQRSMDVEKKAANADSCSVSTSSINVDDADVALRFLKQNGLDESSTANEDDVVAGEEANFYGSHELSPKVLRKVDLFILPFLCCTYLLMFLDKALLNYAASMGIKDHLKGNEFSNLGTIFSAAYIFMEPVVTYLIQKFPISKILGTFITVWGIVLACHAACKTYASLMVVRTLLGLFESSSAVGCIAISGMYYTKSEQSARIGFWATQAGTGYIVGGLISFGFLHYHGTAFTSWQIMFLVVGLVTVAFGVLTFLYLPDNVTNAWFLNKEEKIQVVEHIRANQTGLETKKFKKQQVKELFLHDKFTWPMLLLTACSQISTGAIGTFSVTITGTFGFDKYETALLQLPIGAITAMIILITTQMLSRWGHITLITTSMYIPAIIGCIVLISLPLSHKIGNLFSLYLLYSGSCVITNIYIWNSCNTSGYTKRVFRNAITMIVYNVSCIIAPQMFRAYSAPRYIPAKIALLVTQCVCVPLQLYIGYICKKENEKRDKEQEGQERKKYQFLDLTDIENRNFRYIY |
Proteomic databases
Expression
Induction
Induced by limited extracellular thiamine levels.
Structure
Family & Domains
Sequence similarities
Belongs to the major facilitator superfamily. Allantoate permease family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length523
- Mass (Da)58,531
- Last updated1996-11-01 v1
- Checksum8D6289D98C2ED493
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z73176 EMBL· GenBank· DDBJ | CAA97526.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006945 EMBL· GenBank· DDBJ | DAA09322.1 EMBL· GenBank· DDBJ | Genomic DNA |