Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.Chardin P., Camonis J.H., Gale N.W., van Aelst L., Wigler M.H., Bar-Sagi D.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)TissueBrainCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 260:1338-1343 (1993)Cited in3Mapped to53
The DNA sequence and analysis of human chromosome 14.Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V.[...], Weissenbach J.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 421:601-607 (2003)Cited in99+99+
No title available.Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H.[...], Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (SEP-2005)Cited in99+
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)TissueBrainCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
No title available.Fath I., Apiou F., Dutrillaux B., Tocque B.Cited forNUCLEOTIDE SEQUENCE [MRNA] OF 724-1296 (ISOFORM 1/2)TissuePlacentaCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (MAR-1996)Cited in1
Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.Yamamoto G.L., Aguena M., Gos M., Hung C., Pilch J., Fahiminiya S., Abramowicz A., Cristian I., Buscarilli M.[...], Bertola D.R.View abstractCited forINVOLVEMENT IN NS9, VARIANTS NS9 LYS-267; LYS-310; HIS-334; SER-376 AND LEU-1092, VARIANTS ALA-449 AND ASN-952CategoriesSequences, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Med. Genet. 52:413-421 (2015)Cited in2Mapped to8
Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.Alberts A.S., Treisman R.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCEMBO J. 17:4075-4085 (1998)Cited in1Mapped to81
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.Manser E., Loo T.-H., Koh C.-G., Zhao Z.-S., Chen X.-Q., Tan L., Tan I., Leung T., Lim L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCMol. Cell 1:183-192 (1998)Cited in1Mapped to79
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.Nimnual A.S., Yatsula B.A., Bar-Sagi D.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCScience 279:560-563 (1998)Mapped to66
Rho GTPases and signaling networks.Van Aelst L., D'Souza-Schorey C.AnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCGenes Dev 11:2295-2322 (1997)Mapped to92
Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15.Adunyah S.E., Wheeler B.J., Cooper R.S.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCBiochem Biophys Res Commun 232:754-758 (1997)Mapped to10
Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway.Teramoto H., Salem P., Robbins K.C., Bustelo X.R., Gutkind J.S.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCJ Biol Chem 272:10751-10755 (1997)Mapped to66
Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases.Olson M.F., Pasteris N.G., Gorski J.L., Hall A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCCurr Biol 6:1628-1633 (1996)Mapped to66
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.Crespo P., Schuebel K.E., Ostrom A.A., Gutkind J.S., Bustelo X.R.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCNature 385:169-172 (1997)Mapped to73
Identification of a novel guanine nucleotide exchange factor for the rho GTPase.Hart M.J., Sharma S., el Masry N., Qiu R.-G., McCabe P., Polakis P., Bollag G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCJ. Biol. Chem. 271:25452-25458 (1996)Cited in1Mapped to77
The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac- specific and rho-specific guanine nucleotide exchange factor domains.Debant A., Serra-Pages C., Seipel K., O'Brien S., Tang M., Park S.-H., Streuli M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 93:5466-5471 (1996)Cited in1Mapped to77
A role for Rac in Tiam1-induced membrane ruffling and invasion.Michiels F., Habets G.G.M., Stam J.C., van der Kammen R.A., Collard J.G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCNature 375:338-340 (1995)Cited in1Mapped to77
Direct involvement of the small GTP-binding protein Rho in lbc oncogene function.Zheng Y., Olson M.F., Hall A., Cerione R.A., Toksoz D.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCJ Biol Chem 270:9031-9034 (1995)Mapped to96
Differential interactions of human Sos1 and Sos2 with Grb2.Yang S.S., Van Aelst L., Bar-Sagi D.View abstractCategoriesInteractionSourceIntAct: Q07890PubMedEurope PMCJ Biol Chem 270:18212-18215 (1995)Mapped to3
Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.Chuang T.H., Xu X., Kaartinen V., Heisterkamp N., Groffen J., Bokoch G.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 92:10282-10286 (1995)Cited in2Mapped to99+
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.Smith C.R., Chen D., Christensen J.G., Coulombe R., Fethiere J., Gunn R.J., Hollander J., Jones B., Ketcham J.M.[...], Ivetac A.View abstractCategoriesStructureSourcePDB: 8T5G, PDB: 8T5M, PDB: 8T5R, PDB: 8UC9, PDB: 8UF2, PDB: 8UH0PubMedEurope PMCJ Med Chem 67:774-781 (2024)Mapped to1
Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients.Lin Q., Qiu M., Wei X., Xiang Z., Zhou Z., Ji I., Liang X., Zhou X., Wen Q.[...], Yu H.View abstractAnnotationGenetic variants of SOS2 MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients.CategoriesFunctionSourceGeneRif: 6655PubMedEurope PMCArch Toxicol 97:1599-1611 (2023)Mapped to13
First prenatal case of Noonan syndrome with SOS2 mutation: Implications of early diagnosis for genetic counseling.Gentile M., Fanelli T., Lepri F.R., Gentile A., Orsini P., Volpe P., Novelli A., Ficarella R.View abstractAnnotationFirst prenatal case of Noonan syndrome with SOS2 mutation: Implications of early diagnosis for genetic counseling.CategoriesSequencesSourceGeneRif: 6655PubMedEurope PMCAm J Med Genet A 185:1897-1902 (2021)Mapped to6
Variants of SOS2 are a rare cause of Noonan syndrome with particular predisposition for lymphatic complications.Lissewski C., Chune V., Pantaleoni F., De Luca A., Capri Y., Brinkmann J., Lepri F., Daniele P., Leenders E.[...], Zenker M.View abstractAnnotationVariants of SOS2 are a rare cause of Noonan syndrome with particular predisposition for lymphatic complications.CategoriesSequencesSourceGeneRif: 6655PubMedEurope PMCEur J Hum Genet 29:51-60 (2021)Mapped to6
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.Mueller P.M., Rademacher J., Bagshaw R.D., Wortmann C., Barth C., van Unen J., Alp K.M., Giudice G., Eccles R.L.[...], Rocks O.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-167221PubMedEurope PMCNat. Cell Biol. 22:498-511 (2020)Cited in3Mapped to99+