Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon.Kesti T., Frantti H., Syvaeoja J.E.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 48-51; 876-886 AND 1338-1344TissueT-cellCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 268:10238-10245 (1993)Cited in1
No title available.Syvaeoja J.E.Cited forSEQUENCE REVISIONCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (JUN-1998)Cited in1
No title available.Asahara H., Goldsmith J.S., Lee E., Linn S.Cited forNUCLEOTIDE SEQUENCE [MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (FEB-1996)Cited in1
No title available.NIEHS SNPs programCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-2286CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (APR-2003)Cited in13
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.Li Y., Pursell Z.F., Linn S.View abstractCited forFUNCTION, IDENTIFICATION IN EPSILON DNA POLYMERASE COMPLEXTissueCervix carcinomaCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 275:23247-23252 (2000)Cited in4Mapped to3
BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.Maekiniemi M., Hillukkala T., Tuusa J., Reini K., Vaara M., Huang D., Pospiech H., Majuri I., Westerling T.[...], Syvaeoja J.E.View abstractCited forINTERACTION WITH TOPBP1CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 276:30399-30406 (2001)Cited in2
The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.Post S.M., Tomkinson A.E., Lee E.Y.-H.P.View abstractCited forINTERACTION WITH RAD17CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNucleic Acids Res. 31:5568-5575 (2003)Cited in3
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.[...], Elledge S.J.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1940, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueEmbryonic kidneyCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 316:1160-1166 (2007)Cited in99+99+Mapped to23
Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.Ogi T., Limsirichaikul S., Overmeer R.M., Volker M., Takenaka K., Cloney R., Nakazawa Y., Niimi A., Miki Y.[...], Lehmann A.R.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell 37:714-727 (2010)Cited in6Mapped to62
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S.[...], Mann M.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueCervix carcinomaCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCSci. Signal. 3:RA3-RA3 (2010)Cited in99+99+Mapped to4
Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBMC Syst. Biol. 5:17-17 (2011)Cited in99+99+
Polymerase epsilon1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature (FILS syndrome).Pachlopnik Schmid J., Lemoine R., Nehme N., Cormier-Daire V., Revy P., Debeurme F., Debre M., Nitschke P., Bole-Feysot C.[...], de Saint Basile G.View abstractCited forINVOLVEMENT IN FILSCategoriesDisease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Exp. Med. 209:2323-2330 (2012)Cited in1Mapped to9
Toward a comprehensive characterization of a human cancer cell phosphoproteome.Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1297 AND SER-1317, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueCervix carcinoma, ErythroleukemiaCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Proteome Res. 12:260-271 (2013)Cited in99+99+
Structure of a human replisome shows the organisation and interactions of a DNA replication machine.Jones M.L., Baris Y., Taylor M.R.G., Yeeles J.T.P.View abstractCited forSTRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) IN COMPLEX WITH REPLISOMECategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 40:e108819-e108819 (2021)Cited in17
A conserved mechanism for regulating replisome disassembly in eukaryotes.Jenkyn-Bedford M., Jones M.L., Baris Y., Labib K.P.M., Cannone G., Yeeles J.T.P., Deegan T.D.View abstractCited forSTRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS) IN COMPLEX WITH REPLISOMECategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 600:743-747 (2021)Cited in22Mapped to17
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.CORGI Consortium, WGS500 ConsortiumPalles C., Cazier J.B., Howarth K.M., Domingo E., Jones A.M., Broderick P., Kemp Z., Spain S.L., Guarino Almeida E.[...], Tomlinson I.View abstractCited forVARIANTS CRCS12 LEU-411 AND VAL-424, VARIANTS THR-189; HIS-231; HIS-286; SER-367; ARG-436; PHE-459; TRP-762; ASN-777; ASN-1008; VAL-1255; MET-1368; SER-1421; ASN-1752; ASN-2013; THR-2056 AND VAL-2213CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Genet. 45:136-144 (2013)Cited in3Mapped to13
New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis.Valle L., Hernandez-Illan E., Bellido F., Aiza G., Castillejo A., Castillejo M.I., Navarro M., Segui N., Vargas G.[...], Blanco I.View abstractCited forVARIANT CRCS12 VAL-424CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCHum. Mol. Genet. 23:3506-3512 (2014)Cited in2Mapped to9
A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine.Hansen M.F., Johansen J., Bjoernevoll I., Sylvander A.E., Steinsbekk K.S., Saetrom P., Sandvik A.K., Drabloes F., Sjursen W.View abstractCited forVARIANT CRCS12 PHE-458CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCFam. Cancer 14:437-448 (2015)Cited in3Mapped to9
A novel germline POLE mutation causes an early onset cancer prone syndrome mimicking constitutional mismatch repair deficiency.Wimmer K., Beilken A., Nustede R., Ripperger T., Lamottke B., Ure B., Steinmann D., Reineke-Plaass T., Lehmann U.[...], Kratz C.P.View abstractCited forFUNCTION, VARIANT CRCS12 LEU-411CategoriesFunction, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCFam. Cancer 16:67-71 (2017)Cited in1
The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy.Ahn S.M., Ansari A.A., Kim J., Kim D., Chun S.M., Kim J., Kim T.W., Park I., Yu C.S., Jang S.J.View abstractCited forVARIANTS ARG-286; CYS-1382 AND THR-1925CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncotarget 7:68638-68649 (2016)Cited in1Mapped to9
DNA polymerase epsilon deficiency causes IMAGe syndrome with variable immunodeficiency.SGP ConsortiumLogan C.V., Murray J.E., Parry D.A., Robertson A., Bellelli R., Tarnauskaite Z., Challis R., Cleal L., Borel V.[...], Jackson A.P.View abstractCited forVARIANTS IMAGEI 683-TYR--HIS-2286 DEL; PRO-1007 AND 1980-TRP--HIS-2286 DEL, INVOLVEMENT IN IMAGEICategoriesSequences, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAm. J. Hum. Genet. 103:1038-1044 (2018)Cited in1Mapped to9
Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair.Balajee A.S., May A., Dianova I., Bohr V.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-68473PubMedEurope PMCMutat Res 409:135-146 (1998)Mapped to59
Mammalian base excision repair by DNA polymerases delta and epsilon.Stucki M., Pascucci B., Parlanti E., Fortini P., Wilson S.H., Hubscher U., Dogliotti E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-68473PubMedEurope PMCOncogene 17:835-843 (1998)Mapped to19
DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories.Montecucco A., Rossi R., Levin D.S., Gary R., Park M.S., Motycka T.A., Ciarrocchi G., Villa A., Biamonti G., Tomkinson A.E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-68473PubMedEurope PMCEMBO J 17:3786-3795 (1998)Mapped to19
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).Klungland A., Lindahl T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-68473PubMedEurope PMCEMBO J 16:3341-3348 (1997)Mapped to27