Q07427 · K1C18_CARAU

Function

function

When phosphorylated, plays a role in filament reorganization.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Features

Showing features for site.

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TypeIDPosition(s)Description
Site246-247Cleavage; by caspases
Site339Stutter

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentintermediate filament
Molecular Functionstructural molecule activity

Names & Taxonomy

Protein names

  • Recommended name
    Keratin, type I cytoskeletal 18
  • Alternative names
    • Cytokeratin-18 (CK-18)
    • Keratin-18 (K18)

Gene names

    • Name
      krt18

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Cyprininae > Carassius

Accessions

  • Primary accession
    Q07427

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00002890712-435Keratin, type I cytoskeletal 18

Post-translational modification

Phosphorylated.
Proteolytically cleaved by caspases during epithelial cell apoptosis.

Keywords

Expression

Tissue specificity

Abundantly expressed in an even distribution throughout the optic nerve, localizing specifically to the astrocyte domains. Moderately expressed in spinal cord, brain, liver and oocytes.

Interaction

Subunit

Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-36Disordered
Region2-88Head
Region89-123Coil 1A
Domain89-399IF rod
Region124-140Linker 1
Region141-232Coil 1B
Region233-256Linker 12
Region257-394Coil 2
Region395-435Tail

Sequence similarities

Belongs to the intermediate filament family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    435
  • Mass (Da)
    49,179
  • Last updated
    1996-11-01 v1
  • Checksum
    C5346F321732ABA7
MSLRSSYSVRSSTSQVPVSQMSQMSQMSIKRTTNVPTYRAARSTAAAGQGTRISSASYSGVRSGVGLPSMSSSIHVSATGATGDIMGNEKMAMQNLNDRLASYLRSETLEQANSKLELKIREALEKKGPEVCDYSRFQPIIDDLRRKIFDATSNNARLVLQIDNARLAADDFRVKYDSELSIRQGVEADIAGLRKVIDDTNMNRMNLESEIEALKEELIFLKKNHDNEVMELRNQISHSGVQVDVDAPKGQDLAKIMEEIRSKYEKMALKNQEELKAWHESQITEVQVQVIQNTEALEGARTEVNELRRQIQTLEIELESQRNLKGSLEATLRDTEMRYNMEIESLNAVTMQLEAELTQLRNNIQHQTQEYEALLNLKMKLEAEIATYRRLLDGGDFKLQDALEEQKRVKVMTVTQTLVDGKVVSSSTETKEKKF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L09744
EMBL· GenBank· DDBJ
AAC38007.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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