Q06SM3 · Q06SM3_STECO
- Proteinsuccinate dehydrogenase
- GeneSDHA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids494 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. Can act as a tumor suppressor.
Catalytic activity
- (R)-malate + a quinone = enol-oxaloacetate + a quinolThis reaction proceeds in the forward direction.
- (S)-malate + a quinone = enol-oxaloacetate + a quinolThis reaction proceeds in the forward direction.
Cofactor
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 276 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | electron transfer activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | succinate dehydrogenase (quinone) activity | |
Biological Process | mitochondrial electron transport, succinate to ubiquinone | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namesuccinate dehydrogenase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Delphinidae > Stenella
Accessions
- Primary accessionQ06SM3
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 35 | Tele-8alpha-FAD histidine | |||
Interaction
Subunit
Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment. Interacts with TRAP1. Interacts with LACC1.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-393 | FAD-dependent oxidoreductase 2 FAD binding | |||
Domain | 448-494 | Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal | |||
Sequence similarities
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
Family and domain databases
Sequence
- Sequence statusFragment
- Length494
- Mass (Da)53,515
- Last updated2006-10-31 v1
- Checksum0DAA68A71A43F694
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 494 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ533607 EMBL· GenBank· DDBJ | ABF83576.1 EMBL· GenBank· DDBJ | mRNA |