Q06891 · RAF_YEAST

Function

function

Plays a role in 2-micron plasmid partitioning. Antagonizes transcriptional repression of recombinase FLP by REP1-REP2 (PubMed:2832156).
Regulates both stability and copy number of the plasmid by blocking the formation of the REP1-REP2 repressor complex (PubMed:28472368).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Biological Processplasmid maintenance
Biological Processplasmid partitioning

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Trans-acting factor D
  • Alternative names
    • REP-antagonizing factor
    • Recombinase-activating factor
      (RAF)

Gene names

    • Name
      RAF1
    • Ordered locus names
      R0030W

Encoded on

  • Plasmid 2-micron

Organism names

Accessions

  • Primary accession
    Q06891
  • Secondary accessions
    • Q06966
    • Q06977

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant33in strain: ATCC 7754
Natural variant36in strain: ATCC 7754
Natural variant46-51in strain: ATCC 7754
Natural variant67-68in strain: ATCC 7754
Natural variant104in strain: ATCC 7754
Natural variant116in strain: ATCC 7754
Natural variant125in strain: ATCC 7754
Natural variant136in strain: ATCC 7754
Natural variant137in strain: ATCC 4108
Natural variant144in strain: ATCC 7754
Natural variant152-157in strain: ATCC 7754
Natural variant162in strain: ATCC 7754
Natural variant171in strain: ATCC 7754
Natural variant180in strain: ATCC 7754

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 14 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002836511-181Trans-acting factor D

Proteomic databases

Expression

Induction

Repressed by the negative regulatory complex REP1-REP2.

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    181
  • Mass (Da)
    21,290
  • Last updated
    1996-11-01 v1
  • Checksum
    260CF848B0A51544
MPYKTAIDCIEELATQCFLSKLTDDDVSTFRRVCSKENDIIKLALRIPRTIDYTSILRLLYDTLPLRSLSFNEALPLFCYSIDPAQQRQCDLRFYLRDVVKLARPRKRLEMQKALLQWLPSLLSDVTLQLLNDIRIRFEEIQPNIRQTVLQIYDRTCYPSLNFEHPNLGVFPETDSIFEPV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J01347
EMBL· GenBank· DDBJ
AAB59342.1
EMBL· GenBank· DDBJ
Genomic DNA
M57897
EMBL· GenBank· DDBJ
AAA34955.1
EMBL· GenBank· DDBJ
Genomic DNA
M57898
EMBL· GenBank· DDBJ
AAA34956.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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