Q06891 · RAF_YEAST
- ProteinTrans-acting factor D
- GeneRAF1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids181 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Plays a role in 2-micron plasmid partitioning. Antagonizes transcriptional repression of recombinase FLP by REP1-REP2 (PubMed:2832156).
Regulates both stability and copy number of the plasmid by blocking the formation of the REP1-REP2 repressor complex (PubMed:28472368).
Regulates both stability and copy number of the plasmid by blocking the formation of the REP1-REP2 repressor complex (PubMed:28472368).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Biological Process | plasmid maintenance | |
Biological Process | plasmid partitioning |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTrans-acting factor D
- Alternative names
Gene names
Encoded on
- Plasmid 2-micron
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ06891
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 33 | in strain: ATCC 7754 | ||||
Sequence: V → A | ||||||
Natural variant | 36 | in strain: ATCC 7754 | ||||
Sequence: K → R | ||||||
Natural variant | 46-51 | in strain: ATCC 7754 | ||||
Sequence: RIPRTI → KVPQTV | ||||||
Natural variant | 67-68 | in strain: ATCC 7754 | ||||
Sequence: RS → KF | ||||||
Natural variant | 104 | in strain: ATCC 7754 | ||||
Sequence: R → K | ||||||
Natural variant | 116 | in strain: ATCC 7754 | ||||
Sequence: L → S | ||||||
Natural variant | 125 | in strain: ATCC 7754 | ||||
Sequence: D → N | ||||||
Natural variant | 136 | in strain: ATCC 7754 | ||||
Sequence: I → T | ||||||
Natural variant | 137 | in strain: ATCC 4108 | ||||
Sequence: R → H | ||||||
Natural variant | 144 | in strain: ATCC 7754 | ||||
Sequence: N → D | ||||||
Natural variant | 152-157 | in strain: ATCC 7754 | ||||
Sequence: IYDRTC → NYGRTG | ||||||
Natural variant | 162 | in strain: ATCC 7754 | ||||
Sequence: N → D | ||||||
Natural variant | 171 | in strain: ATCC 7754 | ||||
Sequence: F → L | ||||||
Natural variant | 180 | in strain: ATCC 7754 | ||||
Sequence: P → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 14 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000283651 | 1-181 | Trans-acting factor D | |||
Sequence: MPYKTAIDCIEELATQCFLSKLTDDDVSTFRRVCSKENDIIKLALRIPRTIDYTSILRLLYDTLPLRSLSFNEALPLFCYSIDPAQQRQCDLRFYLRDVVKLARPRKRLEMQKALLQWLPSLLSDVTLQLLNDIRIRFEEIQPNIRQTVLQIYDRTCYPSLNFEHPNLGVFPETDSIFEPV |
Proteomic databases
Expression
Induction
Repressed by the negative regulatory complex REP1-REP2.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length181
- Mass (Da)21,290
- Last updated1996-11-01 v1
- Checksum260CF848B0A51544
Keywords
- Technical term