Q06671 · ATG23_YEAST

Function

function

Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9. Also plays a role in regulation of filamentous growth.

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentphagophore assembly site
Cellular Componentphagophore assembly site membrane
Biological Processcytoplasm to vacuole targeting by the Cvt pathway
Biological Processnucleophagy
Biological Processpositive regulation of macroautophagy
Biological Processprotein localization to phagophore assembly site

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 9.A.15.1.1the autophagy-related phagophore-formation transporter (apt) family

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 23
  • Alternative names
    • Cytoplasm to vacuole targeting protein 23

Gene names

    • Name
      ATG23
    • Synonyms
      CVT23
    • Ordered locus names
      YLR431C

Organism names

Accessions

  • Primary accession
    Q06671
  • Secondary accessions
    • D6VZ66

Proteomes

Organism-specific databases

Subcellular Location

Preautophagosomal structure membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Note: Found in pre-autophagosomal structure and other punctate structures. Correct localization of ATG23 to the membranes is strictly dependent of ATG9. Cycling through the pre-autophagosomal structure and correct location to other punctate structures is ATG1- and ATG13-dependent.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000647271-453

Proteomic databases

PTM databases

Interaction

Subunit

Forms a complex with ATG9 and ATG27.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil144-213
Coiled coil272-302
Region381-453Disordered
Compositional bias406-426Polar residues

Sequence similarities

Belongs to the ATG23 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    453
  • Mass (Da)
    51,540
  • Last updated
    1996-11-01 v1
  • Checksum
    D6F497DE0677FA20
MELNQVLEKKEQILQYLGTLVGLHEKALSDVNSASQVTSIRKDITICLNDLCRINDLLVSHDGLLKREIGSLLRDKQELLELNEREQLLWKERKSWHIKQETDAAPADYVIDKDAIITISSHHRTSLNKYIESVGAENTILSNTDDSDAMIEEVQNAESSADQMIRNYKLLQLSHKQAKSEIIRLETLLRDFKKDNKFIEEELKRQSGRIRSEMGNIDFHLSKIEESKHQLMKRIGFESPLTQEKSLSEKIFNLRLSSADEDYNERQTINMKNFVHMKDLIELKIEDLQEQLMRNKNESSTVLTQRELWLDCQKKVGDLESKLITKLRSSSNSKIPPNEMSEMINSTIQYLNNLLDSSDEKLTTTLISNERDVLSKACEELHSESTTAQDGSSALPSKPIDIHKSHKGSNASSNLKQPSTPSFLVASKSPPKIGISESVVNANKNDAISKKVE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias406-426Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U21094
EMBL· GenBank· DDBJ
AAB67517.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006945
EMBL· GenBank· DDBJ
DAA09732.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp