Q06389 · NCS1_YEAST

Function

function

Regulator of phosphatidylinositol 4-kinase PIK1.

Miscellaneous

Binds 3 calcium ions via the second, third and fourth EF-hand.
Present with 7160 molecules/cell in log phase SD medium.

Features

Showing features for binding site.

119020406080100120140160180
TypeIDPosition(s)Description
Binding site73Ca2+ 1 (UniProtKB | ChEBI)
Binding site75Ca2+ 1 (UniProtKB | ChEBI)
Binding site77Ca2+ 1 (UniProtKB | ChEBI)
Binding site79Ca2+ 1 (UniProtKB | ChEBI)
Binding site84Ca2+ 1 (UniProtKB | ChEBI)
Binding site109Ca2+ 2 (UniProtKB | ChEBI)
Binding site111Ca2+ 2 (UniProtKB | ChEBI)
Binding site113Ca2+ 2 (UniProtKB | ChEBI)
Binding site115Ca2+ 2 (UniProtKB | ChEBI)
Binding site120Ca2+ 2 (UniProtKB | ChEBI)
Binding site157Ca2+ 3 (UniProtKB | ChEBI)
Binding site159Ca2+ 3 (UniProtKB | ChEBI)
Binding site161Ca2+ 3 (UniProtKB | ChEBI)
Binding site163Ca2+ 3 (UniProtKB | ChEBI)
Binding site168Ca2+ 3 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcellular bud membrane
Cellular Componentcytosol
Cellular ComponentGolgi membrane
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionenzyme activator activity
Biological Processregulation of signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Calcium-binding protein NCS-1

Gene names

    • Name
      FRQ1
    • Synonyms
      NCS1
    • ORF names
      D9481.6
    • Ordered locus names
      YDR373W

Organism names

Accessions

  • Primary accession
    Q06389
  • Secondary accessions
    • D6VT04

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis2Abolishes N-myristoylation.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00000737952-190Calcium-binding protein NCS-1

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Binds PIK1.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q06389PEX14 P531123EBI-11946, EBI-13212
BINARY Q06389PIK1 P391044EBI-11946, EBI-13423

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-59EF-hand 1
Domain60-95EF-hand 2
Domain96-131EF-hand 3
Domain144-179EF-hand 4

Sequence similarities

Belongs to the recoverin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    190
  • Mass (Da)
    22,011
  • Last updated
    2007-01-23 v2
  • Checksum
    5E9D7F48F8AADA21
MGAKTSKLSKDDLTCLKQSTYFDRREIQQWHKGFLRDCPSGQLAREDFVKIYKQFFPFGSPEDFANHLFTVFDKDNNGFIHFEEFITVLSTTSRGTLEEKLSWAFELYDLNHDGYITFDEMLTIVASVYKMMGSMVTLNEDEATPEMRVKKIFKLMDKNEDGYITLDEFREGSKVDPSIIGALNLYDGLI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U28373
EMBL· GenBank· DDBJ
AAB64809.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006938
EMBL· GenBank· DDBJ
DAA12214.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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