Q06316 · BLAC_AMYLA
- ProteinBeta-lactamase
- Genebla
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids302 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Active on penicillins but not on cephalosporins.
Miscellaneous
The class A beta-lactamase family has a specific amino-acid numbering system, sometimes called Ambler or ABL numbering and often misspelt as Amber. A multiple sequence alignment was used to derive a consensus sequence and then the consensus was numbered taking into account insertions and deletions. This allows use of identical numbers, e.g. for active site residues, despite differences in protein length. UniProt always uses natural numbering of residues, hence there appear to be differences in numbering between this entry and some papers.
Catalytic activity
- a beta-lactam + H2O = a substituted beta-amino acid
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 85 | Acyl-ester intermediate | |||
Site | 88 | Increases nucleophilicity of active site Ser | |||
Binding site | 143 | substrate | |||
Active site | 179 | Proton acceptor | |||
Binding site | 247-249 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | beta-lactamase activity | |
Biological Process | beta-lactam antibiotic catabolic process | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-lactamase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Amycolatopsis
Accessions
- Primary accessionQ06316
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-29 | ||||
Chain | PRO_0000017006 | 30-302 | Beta-lactamase | ||
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length302
- Mass (Da)32,084
- Last updated1994-06-01 v1
- MD5 Checksum03B03A0857F1C3037CE4B46B24D358E5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 16-41 | Pro residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z13971 EMBL· GenBank· DDBJ | CAA78373.1 EMBL· GenBank· DDBJ | Genomic DNA |