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Q06316 · BLAC_AMYLA

Function

function

Active on penicillins but not on cephalosporins.

Miscellaneous

The class A beta-lactamase family has a specific amino-acid numbering system, sometimes called Ambler or ABL numbering and often misspelt as Amber. A multiple sequence alignment was used to derive a consensus sequence and then the consensus was numbered taking into account insertions and deletions. This allows use of identical numbers, e.g. for active site residues, despite differences in protein length. UniProt always uses natural numbering of residues, hence there appear to be differences in numbering between this entry and some papers.

Catalytic activity

Features

Showing features for active site, site, binding site.

130220406080100120140160180200220240260280300
Type
IDPosition(s)Description
Active site85Acyl-ester intermediate
Site88Increases nucleophilicity of active site Ser
Binding site143substrate
Active site179Proton acceptor
Binding site247-249substrate

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionbeta-lactamase activity
Biological Processbeta-lactam antibiotic catabolic process
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-lactamase
  • EC number
  • Alternative names
    • Penicillinase

Gene names

    • Name
      bla

Organism names

Accessions

  • Primary accession
    Q06316

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-29
ChainPRO_000001700630-302Beta-lactamase

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-43Disordered
Compositional bias16-41Pro residues

Sequence similarities

Belongs to the class-A beta-lactamase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    302
  • Mass (Da)
    32,084
  • Last updated
    1994-06-01 v1
  • MD5 Checksum
    03B03A0857F1C3037CE4B46B24D358E5
MADRRRVHAWARARPAAPEPAPPTPSAAAPSVAPGPAATPPDPAVEQEFTRLQTQYDARLGLYAVDTGSGESVAFRADERFAFASTFKALAAAAVLDSTTPQQLDQVVRYSKDELLENSPITKDHVATGMTLRELCDAAVRFSDNTAGNLLLKHVGGPQGLDAALTAVGDEVTSADRWEPELNSAVPGDVRDTSTPRALAHDLRQFVLGDALAEDDRALLTDWLRRNTTGGTVIRAGVPADWVVGDKTGSGYYGGRNDIAVLWPPNRAPIVMAVMTSREEPRAKRADALLADAARVAVTALG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias16-41Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z13971
EMBL· GenBank· DDBJ
CAA78373.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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