Q06184 · TEB_EUPCR

  • Protein
    Telomere-binding protein 51 kDa subunit
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear telomere cap complex
Molecular FunctionG-rich strand telomeric DNA binding
Molecular Functiontelomerase inhibitor activity
Biological Processregulation of telomere maintenance via telomerase
Biological Processtelomere capping

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Telomere-binding protein 51 kDa subunit

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Ciliophora > Intramacronucleata > Spirotrichea > Hypotrichia > Euplotida > Euplotidae > Moneuplotes

Accessions

  • Primary accession
    Q06184

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001217331-446Telomere-binding protein 51 kDa subunit

Interaction

Subunit

Monomer.

Structure

Family & Domains

Sequence similarities

Belongs to the telombin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    446
  • Mass (Da)
    51,544
  • Last updated
    1994-06-01 v1
  • Checksum
    EF702F1E161990E3
MPKQKAAKKDHYQYSDLSSIKKEGEEDQYHFYGVVIDASFPYKGEKRYVVTCKVADPSSVAKGGKLNTVNVVFFSQNFEDLPIIQRVGDIVRVHRARLQHYNDAKQLNVNMYYRSSWCLFIGNDKEAPLEPKVENEDGTNNYFSYTPYNFSGKSFTQEGHETKILKDLKKWSKDYFSNNDVVEQVKKADIETAMKNKTDFDLLAKVTEISDNDQYTNTVSLNDSTGQTWTGHLFKRKFPHLVKGDVLRIKSVSAKEDNSLIFSSHSNILKFFSFSSIHKKLKSSISSDTHIKTCVTKIDKAAHNKMDITPLKKLFFNPKKSEKLFRSQFSVLKVDTKNLEDYVGAFDGKKWHSYKGKKTPKDAELRWNIKLIVTDYKNQQDDKAYMIHLDDNSFFKGINPANWSNAATKKKAEKAFSVLTNNKVNYVDAILERDKKNYHIRHTQFK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M96818
EMBL· GenBank· DDBJ
AAA29127.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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