Q06124 · PTN11_HUMAN
- ProteinTyrosine-protein phosphatase non-receptor type 11
- GenePTPN11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids593 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Positively regulates MAPK signal transduction pathway (PubMed:28074573).
Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573).
Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669).
Dephosphorylates CDC73 (PubMed:26742426).
Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).
Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884).
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 425 | substrate | ||||
Sequence: D | ||||||
Active site | 459 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 459-465 | substrate | ||||
Sequence: CSAGIGR | ||||||
Binding site | 506 | substrate | ||||
Sequence: Q |
GO annotations
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein phosphatase non-receptor type 11
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ06124
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Involvement in disease
LEOPARD syndrome 1 (LPRD1)
- Note
- DescriptionA disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness.
- See alsoMIM:151100
Natural variants in LPRD1
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_015614 | 279 | Y>C | in NS1 and LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs121918456 | |
VAR_027188 | 279 | Y>S | in LPRD1; dbSNP:rs121918456 | |
VAR_027190 | 461 | A>T | in LPRD1; dbSNP:rs121918468 | |
VAR_027191 | 464 | G>A | in LPRD1; dbSNP:rs121918469 | |
VAR_015621 | 468 | T>M | in LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs121918457 | |
VAR_027192 | 498 | R>L | in LPRD1; dbSNP:rs397507542 | |
VAR_027193 | 498 | R>W | in LPRD1; reduced phosphatase activity; dbSNP:rs397507541 | |
VAR_027194 | 506 | Q>P | in LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs397507548 | |
VAR_076499 | 510 | Q>E | in NS1 and LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs397507549 | |
VAR_027196 | 510 | Q>P | in LPRD1; dbSNP:rs121918470 |
Noonan syndrome 1 (NS1)
- Note
- DescriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. Some patients with NS1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villonodular synovitis (PVNS) when occurring in the jaw or joints.
- See alsoMIM:163950
Natural variants in NS1
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_027183 | 2 | T>I | in NS1; dbSNP:rs267606990 | |
VAR_015601 | 42 | T>A | in NS1; dbSNP:rs397507501 | |
VAR_027184 | 58 | N>K | in NS1; dbSNP:rs397507506 | |
VAR_066060 | 59 | T>A | in NS1; dbSNP:rs886043790 | |
VAR_015602 | 60 | G>A | in NS1; dbSNP:rs397507509 | |
VAR_015603 | 61 | D>G | in NS1; dbSNP:rs121918461 | |
VAR_015604 | 61 | D>N | in NS1; dbSNP:rs397507510 | |
VAR_015605 | 62 | Y>D | in NS1; also in Noonan patients manifesting juvenile myelomonocytic leukemia; dbSNP:rs121918460 | |
VAR_015606 | 63 | Y>C | in NS1; dbSNP:rs121918459 | |
VAR_027185 | 69 | E>Q | in NS1; dbSNP:rs397507511 | |
VAR_015995 | 71 | F>L | in NS1; also found in myelodysplastic syndrome; dbSNP:rs397507512 | |
VAR_015607 | 72 | A>G | in NS1; dbSNP:rs121918454 | |
VAR_015608 | 72 | A>S | in NS1; dbSNP:rs121918453 | |
VAR_015609 | 73 | T>I | in NS1; also in Noonan patients manifesting juvenile myelomonocytic leukemia; dbSNP:rs121918462 | |
VAR_015610 | 76 | E>D | in NS1; dbSNP:rs397507514 | |
VAR_027186 | 79 | Q>P | in NS1 | |
VAR_015611 | 79 | Q>R | in NS1; dbSNP:rs121918466 | |
VAR_015612 | 106 | D>A | in NS1; dbSNP:rs397507517 | |
VAR_015613 | 139 | E>D | in NS1; dbSNP:rs397507520 | |
VAR_027187 | 256 | Q>R | in NS1; dbSNP:rs397507523 | |
VAR_078101 | 261 | L>F | in NS1; increases MAPK signaling; increases protein tyrosine phosphatase activity; changed substrate selectivity for GAB1; dbSNP:rs397507525 | |
VAR_078102 | 261 | L>H | in NS1; increases MAPK signaling; increased protein tyrosine phosphatase activity; dbSNP:rs765642157 | |
VAR_078103 | 262 | L>F | in NS1; increases MAPK signaling; increased protein tyrosine phosphatase activity; dbSNP:rs2038442836 | |
VAR_078104 | 262 | L>R | in NS1; increases MAPK signaling; increased protein tyrosine phosphatase activity; dbSNP:rs397507526 | |
VAR_078105 | 265 | R>Q | in NS1; increases MAPK signaling; increased protein tyrosine phosphatase activity; dbSNP:rs376607329 | |
VAR_015614 | 279 | Y>C | in NS1 and LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs121918456 | |
VAR_015615 | 282 | I>V | in NS1; dbSNP:rs397507529 | |
VAR_015617 | 285 | F>L | in NS1; dbSNP:rs397507531 | |
VAR_015616 | 285 | F>S | in NS1; dbSNP:rs121918463 | |
VAR_015619 | 308 | N>D | in NS1; common mutation; dbSNP:rs28933386 | |
VAR_015618 | 308 | N>S | in NS1; some patients also manifest giant cell lesions of bone and soft tissue; dbSNP:rs121918455 | |
VAR_015620 | 309 | I>V | in NS1; uncertain significance; dbSNP:rs201787206 | |
VAR_027189 | 411 | T>M | in NS1; dbSNP:rs121918467 | |
VAR_071706 | 491 | P>S | in NS1; increased phosphatase activity; dbSNP:rs397507539 | |
VAR_015622 | 501 | R>K | in NS1; dbSNP:rs397507543 | |
VAR_015623 | 502 | S>T | in NS1; dbSNP:rs121918458 | |
VAR_016003 | 503 | G>R | in NS1 and JMML; JMML patient also shows growth retardation and pulmonic stenosis; dbSNP:rs397507545 | |
VAR_015624 | 504 | M>V | in NS1; dbSNP:rs397507547 | |
VAR_027195 | 506 | Q>R | in NS1 | |
VAR_076499 | 510 | Q>E | in NS1 and LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs397507549 | |
VAR_027197 | 560 | L>F | in NS1; uncertain significance; dbSNP:rs397516797 |
Leukemia, juvenile myelomonocytic (JMML)
- Note
- DescriptionAn aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
- See alsoMIM:607785
Natural variants in JMML
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_015991 | 61 | D>V | in JMML; also in myelodysplastic syndrome; dbSNP:rs121918461 | |
VAR_015992 | 61 | D>Y | in JMML; dbSNP:rs397507510 | |
VAR_015993 | 69 | E>K | in JMML; also in myelodysplastic syndrome; dbSNP:rs397507511 | |
VAR_015996 | 72 | A>T | in JMML; dbSNP:rs121918453 | |
VAR_015997 | 72 | A>V | in JMML; dbSNP:rs121918454 | |
VAR_015998 | 76 | E>A | in JMML; also in myelodysplastic syndrome; dbSNP:rs121918465 | |
VAR_015999 | 76 | E>G | in JMML; dbSNP:rs121918465 | |
VAR_016000 | 76 | E>K | in JMML; increases protein tyrosine phosphatase activity against CDC73; dbSNP:rs121918464 | |
VAR_016001 | 76 | E>V | in JMML; dbSNP:rs121918465 | |
VAR_016002 | 503 | G>A | in JMML; dbSNP:rs397507546 | |
VAR_016003 | 503 | G>R | in NS1 and JMML; JMML patient also shows growth retardation and pulmonic stenosis; dbSNP:rs397507545 |
Metachondromatosis (MC)
- Note
- DescriptionA skeletal disorder with radiologic features of both multiple exostoses and Ollier disease, characterized by the presence of exostoses, commonly of the bones of the hands and feet, and enchondromas of the metaphyses of long bones and iliac crest.
- See alsoMIM:156250
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_027183 | 2 | in NS1; dbSNP:rs267606990 | |||
Sequence: T → I | ||||||
Natural variant | VAR_015601 | 42 | in NS1; dbSNP:rs397507501 | |||
Sequence: T → A | ||||||
Natural variant | VAR_027184 | 58 | in NS1; dbSNP:rs397507506 | |||
Sequence: N → K | ||||||
Natural variant | VAR_066060 | 59 | in NS1; dbSNP:rs886043790 | |||
Sequence: T → A | ||||||
Natural variant | VAR_015602 | 60 | in NS1; dbSNP:rs397507509 | |||
Sequence: G → A | ||||||
Natural variant | VAR_015990 | 60 | in myelodysplastic syndrome; dbSNP:rs397507509 | |||
Sequence: G → V | ||||||
Natural variant | VAR_015603 | 61 | in NS1; dbSNP:rs121918461 | |||
Sequence: D → G | ||||||
Natural variant | VAR_015604 | 61 | in NS1; dbSNP:rs397507510 | |||
Sequence: D → N | ||||||
Natural variant | VAR_015991 | 61 | in JMML; also in myelodysplastic syndrome; dbSNP:rs121918461 | |||
Sequence: D → V | ||||||
Natural variant | VAR_015992 | 61 | in JMML; dbSNP:rs397507510 | |||
Sequence: D → Y | ||||||
Natural variant | VAR_015605 | 62 | in NS1; also in Noonan patients manifesting juvenile myelomonocytic leukemia; dbSNP:rs121918460 | |||
Sequence: Y → D | ||||||
Natural variant | VAR_015606 | 63 | in NS1; dbSNP:rs121918459 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_015993 | 69 | in JMML; also in myelodysplastic syndrome; dbSNP:rs397507511 | |||
Sequence: E → K | ||||||
Natural variant | VAR_027185 | 69 | in NS1; dbSNP:rs397507511 | |||
Sequence: E → Q | ||||||
Natural variant | VAR_015994 | 71 | in acute myeloid leukemia; requires 2 nucleotide substitutions | |||
Sequence: F → K | ||||||
Natural variant | VAR_015995 | 71 | in NS1; also found in myelodysplastic syndrome; dbSNP:rs397507512 | |||
Sequence: F → L | ||||||
Natural variant | VAR_015607 | 72 | in NS1; dbSNP:rs121918454 | |||
Sequence: A → G | ||||||
Natural variant | VAR_015608 | 72 | in NS1; dbSNP:rs121918453 | |||
Sequence: A → S | ||||||
Natural variant | VAR_015996 | 72 | in JMML; dbSNP:rs121918453 | |||
Sequence: A → T | ||||||
Natural variant | VAR_015997 | 72 | in JMML; dbSNP:rs121918454 | |||
Sequence: A → V | ||||||
Natural variant | VAR_015609 | 73 | in NS1; also in Noonan patients manifesting juvenile myelomonocytic leukemia; dbSNP:rs121918462 | |||
Sequence: T → I | ||||||
Natural variant | VAR_015998 | 76 | in JMML; also in myelodysplastic syndrome; dbSNP:rs121918465 | |||
Sequence: E → A | ||||||
Natural variant | VAR_015610 | 76 | in NS1; dbSNP:rs397507514 | |||
Sequence: E → D | ||||||
Natural variant | VAR_015999 | 76 | in JMML; dbSNP:rs121918465 | |||
Sequence: E → G | ||||||
Natural variant | VAR_016000 | 76 | in JMML; increases protein tyrosine phosphatase activity against CDC73; dbSNP:rs121918464 | |||
Sequence: E → K | ||||||
Natural variant | VAR_016001 | 76 | in JMML; dbSNP:rs121918465 | |||
Sequence: E → V | ||||||
Natural variant | VAR_027186 | 79 | in NS1 | |||
Sequence: Q → P | ||||||
Natural variant | VAR_015611 | 79 | in NS1; dbSNP:rs121918466 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_015612 | 106 | in NS1; dbSNP:rs397507517 | |||
Sequence: D → A | ||||||
Natural variant | VAR_015613 | 139 | in NS1; dbSNP:rs397507520 | |||
Sequence: E → D | ||||||
Natural variant | VAR_027187 | 256 | in NS1; dbSNP:rs397507523 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_078101 | 261 | in NS1; increases MAPK signaling; increases protein tyrosine phosphatase activity; changed substrate selectivity for GAB1; dbSNP:rs397507525 | |||
Sequence: L → F | ||||||
Natural variant | VAR_078102 | 261 | in NS1; increases MAPK signaling; increased protein tyrosine phosphatase activity; dbSNP:rs765642157 | |||
Sequence: L → H | ||||||
Natural variant | VAR_078103 | 262 | in NS1; increases MAPK signaling; increased protein tyrosine phosphatase activity; dbSNP:rs2038442836 | |||
Sequence: L → F | ||||||
Natural variant | VAR_078104 | 262 | in NS1; increases MAPK signaling; increased protein tyrosine phosphatase activity; dbSNP:rs397507526 | |||
Sequence: L → R | ||||||
Natural variant | VAR_078105 | 265 | in NS1; increases MAPK signaling; increased protein tyrosine phosphatase activity; dbSNP:rs376607329 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_015614 | 279 | in NS1 and LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs121918456 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_027188 | 279 | in LPRD1; dbSNP:rs121918456 | |||
Sequence: Y → S | ||||||
Natural variant | VAR_015615 | 282 | in NS1; dbSNP:rs397507529 | |||
Sequence: I → V | ||||||
Natural variant | VAR_015617 | 285 | in NS1; dbSNP:rs397507531 | |||
Sequence: F → L | ||||||
Natural variant | VAR_015616 | 285 | in NS1; dbSNP:rs121918463 | |||
Sequence: F → S | ||||||
Natural variant | VAR_015619 | 308 | in NS1; common mutation; dbSNP:rs28933386 | |||
Sequence: N → D | ||||||
Natural variant | VAR_015618 | 308 | in NS1; some patients also manifest giant cell lesions of bone and soft tissue; dbSNP:rs121918455 | |||
Sequence: N → S | ||||||
Natural variant | VAR_015620 | 309 | in NS1; uncertain significance; dbSNP:rs201787206 | |||
Sequence: I → V | ||||||
Natural variant | VAR_027189 | 411 | in NS1; dbSNP:rs121918467 | |||
Sequence: T → M | ||||||
Mutagenesis | 459 | Abolishes phosphatase activity. Enhances interaction with NEDD9. | ||||
Sequence: C → S | ||||||
Natural variant | VAR_027190 | 461 | in LPRD1; dbSNP:rs121918468 | |||
Sequence: A → T | ||||||
Natural variant | VAR_027191 | 464 | in LPRD1; dbSNP:rs121918469 | |||
Sequence: G → A | ||||||
Natural variant | VAR_015621 | 468 | in LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs121918457 | |||
Sequence: T → M | ||||||
Natural variant | VAR_071706 | 491 | in NS1; increased phosphatase activity; dbSNP:rs397507539 | |||
Sequence: P → S | ||||||
Natural variant | VAR_027192 | 498 | in LPRD1; dbSNP:rs397507542 | |||
Sequence: R → L | ||||||
Natural variant | VAR_027193 | 498 | in LPRD1; reduced phosphatase activity; dbSNP:rs397507541 | |||
Sequence: R → W | ||||||
Natural variant | VAR_015622 | 501 | in NS1; dbSNP:rs397507543 | |||
Sequence: R → K | ||||||
Natural variant | VAR_015623 | 502 | in NS1; dbSNP:rs121918458 | |||
Sequence: S → T | ||||||
Natural variant | VAR_016002 | 503 | in JMML; dbSNP:rs397507546 | |||
Sequence: G → A | ||||||
Natural variant | VAR_016003 | 503 | in NS1 and JMML; JMML patient also shows growth retardation and pulmonic stenosis; dbSNP:rs397507545 | |||
Sequence: G → R | ||||||
Natural variant | VAR_015624 | 504 | in NS1; dbSNP:rs397507547 | |||
Sequence: M → V | ||||||
Natural variant | VAR_027194 | 506 | in LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs397507548 | |||
Sequence: Q → P | ||||||
Natural variant | VAR_027195 | 506 | in NS1 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_076499 | 510 | in NS1 and LPRD1; does not affect subcellular location; decreases protein tyrosine phosphatase activity against CDC73; dbSNP:rs397507549 | |||
Sequence: Q → E | ||||||
Natural variant | VAR_027196 | 510 | in LPRD1; dbSNP:rs121918470 | |||
Sequence: Q → P | ||||||
Natural variant | VAR_027197 | 560 | in NS1; uncertain significance; dbSNP:rs397516797 | |||
Sequence: L → F |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,631 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | ||||
Sequence: M | |||||||
Modified residue | 2 | UniProt | N-acetylthreonine | ||||
Sequence: T | |||||||
Chain | PRO_0000094767 | 2-593 | UniProt | Tyrosine-protein phosphatase non-receptor type 11 | |||
Sequence: TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR | |||||||
Modified residue (large scale data) | 36 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 59 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 62 | UniProt | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 62 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 63 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue | 66 | UniProt | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 66 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 142 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 279 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue | 542 | UniProt | Phosphotyrosine; by PDGFR | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 542 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 553 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 558 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 564 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 566 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 576 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 580 | UniProt | Phosphotyrosine; by PDGFR | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 580 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 591 | PRIDE | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated by activated PDGFRB
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).
Interacts with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11 phosphatase activity. Interacts with GAREM1 isoform 1 (tyrosine phosphorylated); the interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation. Interacts with CDC73 (PubMed:26742426).
Interacts with CEACAM1 (via cytoplasmic domain); this interaction depends on the monomer/dimer equilibrium and is phosphorylation-dependent (By similarity).
Interacts with MPIG6B (via ITIM motif) (PubMed:23112346).
Interacts with SIGLEC10 (By similarity).
Interacts with FCRL3 (via phosphorylated ITIM motifs) (PubMed:11162587, PubMed:19843936).
Interacts with CLEC12B (via ITIM motif); this interaction triggers dephosphorylation and activation of PTPN11. Interacts (via SH2 domains) with NEDD9/CAS-L; the interaction is enhanced when NEDD9/CAS-L is tyrosine phosphorylated (PubMed:19275884).
Binary interactions
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-102 | SH2 1 | ||||
Sequence: WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL | ||||||
Domain | 112-216 | SH2 2 | ||||
Sequence: WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPL | ||||||
Domain | 247-517 | Tyrosine-protein phosphatase | ||||
Sequence: FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMA | ||||||
Region | 548-571 | Disordered | ||||
Sequence: SLADQTSGDQSPLPPCTPTPPCAE |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q06124-2
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsPTP2C
- Length593
- Mass (Da)68,011
- Last updated2019-12-11 v3
- Checksum9CDBEFFA5E6CCB45
Q06124-1
- Name2
- SynonymsPTP2Ci
- Differences from canonical
- 407-407: G → GQALL
Q06124-3
- Name3
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I5QJ58 | A0A8I5QJ58_HUMAN | PTPN11 | 536 | ||
A0A8I5QL30 | A0A8I5QL30_HUMAN | PTPN11 | 468 | ||
A0A0U1RRI0 | A0A0U1RRI0_HUMAN | PTPN11 | 196 | ||
H0YF12 | H0YF12_HUMAN | PTPN11 | 108 | ||
A0A1W2PPU4 | A0A1W2PPU4_HUMAN | PTPN11 | 578 | ||
A0A8I5KRZ3 | A0A8I5KRZ3_HUMAN | PTPN11 | 555 | ||
A0A8I5KVS6 | A0A8I5KVS6_HUMAN | PTPN11 | 461 | ||
A0A8I5KW48 | A0A8I5KW48_HUMAN | PTPN11 | 671 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_060437 | 407 | in isoform 2 | |||
Sequence: G → GQALL | ||||||
Alternative sequence | VSP_060438 | 460 | in isoform 3 | |||
Sequence: S → R | ||||||
Alternative sequence | VSP_060439 | 461-593 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 535 | in Ref. 3; BAA02740 | ||||
Sequence: S → R | ||||||
Sequence conflict | 548 | in Ref. 3; BAA02740 | ||||
Sequence: S → P |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D13540 EMBL· GenBank· DDBJ | BAA02740.2 EMBL· GenBank· DDBJ | mRNA | ||
L03535 EMBL· GenBank· DDBJ | AAA36611.1 EMBL· GenBank· DDBJ | mRNA | ||
L07527 EMBL· GenBank· DDBJ | AAA17022.1 EMBL· GenBank· DDBJ | mRNA | ||
L08807 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
X70766 EMBL· GenBank· DDBJ | CAA50045.1 EMBL· GenBank· DDBJ | mRNA | ||
BT007106 EMBL· GenBank· DDBJ | AAP35770.1 EMBL· GenBank· DDBJ | mRNA | ||
AK289854 EMBL· GenBank· DDBJ | BAF82543.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471054 EMBL· GenBank· DDBJ | EAW98012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC008692 EMBL· GenBank· DDBJ | AAH08692.1 EMBL· GenBank· DDBJ | mRNA |