Q06031 · GP63_CRIFA

  • Protein
    Leishmanolysin homolog
  • Gene
    gp63
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Plays an integral role during the infection of macrophages in the mammalian host.

Catalytic activity

  • Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.
    EC:3.4.24.36 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

165350100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site276Zn2+ (UniProtKB | ChEBI); catalytic
Active site277
Binding site280Zn2+ (UniProtKB | ChEBI); catalytic
Binding site346Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processcell adhesion
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Leishmanolysin homolog
  • EC number
  • Alternative names
    • Cell surface protease
    • Major surface glycoprotein
    • Protein gp63

Gene names

    • Name
      gp63

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 11745
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Crithidia

Accessions

  • Primary accession
    Q06031

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond, glycosylation, lipidation.

Type
IDPosition(s)Description
Signal1-44
PropeptidePRO_000002865245-113Activation peptide
ChainPRO_0000028653114-628Leishmanolysin homolog
Disulfide bond138↔155
Disulfide bond203↔242
Disulfide bond326↔398
Glycosylation383N-linked (GlcNAc...) asparagine
Disulfide bond405↔468
Glycosylation409N-linked (GlcNAc...) asparagine
Disulfide bond418↔437
Disulfide bond427↔502
Disulfide bond479↔524
Disulfide bond529↔579
Disulfide bond549↔572
Glycosylation569N-linked (GlcNAc...) asparagine
Lipidation628GPI-anchor amidated serine
PropeptidePRO_0000028654629-653Removed in mature form

Keywords

PTM databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias590-625Polar residues
Region590-631Disordered

Sequence similarities

Belongs to the peptidase M8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    653
  • Mass (Da)
    69,171
  • Last updated
    2010-10-05 v2
  • Checksum
    263A1DA7568034B6
MHAPPTATRRSGPRRTHGIMARLVRLAAGVLVVTLVIGALTALSADDAKTHPHKVCIHDELQQSLLDSVAQQGLAPQRVSRVGLPYVASATAAPAAQVGGVDFALAGDSAPDVTRSAEWGELRITVSAEELTDPAYHCATVGQVISNHIDDYVTCTADDIMTAEKLDILMNYLIPEALQMHKDRLQVQQVQGTWKVARMTSYCGRFKVPEEHFTTGLSNTDFVLYVASVPTSPGVLAWANTCQVFSNDQPAVGVINIPAATITERYDHLMVHAVTHEIAHSLGFSNAFFTNTGIGQFVTGVRGNPDTVPVINSPTVVAKAREHYGCDDVTYVELEDAGGSGTMGSHWKIRNAQDELMAGISGVAYYTSLTLSAFEDLGYYKANYSNAETMKWGKDVGCAFLTGKCVVDNVTQFPSMYCDKDENVYRCHTARLNLGSCEVTDYTFDLPDYLQYFTVPSVGGSADYYDYCPYIVRSPIGSCTQAASSASPFVSAFNTFSMASRCIDGTFTPKSTGGATVTAHLGMCTNVACNTADKTYSIQVYGNGAYIPCTPGATISLDTVSDAFEAGGNITCPPYLEVCQSNVKGAMDYESMTNSGSGSSRPAPVEPSGSGSGSSAATTAPSPTRDGSAAADRIAPRTAAVALLALAVAAACV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias590-625Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M94364
EMBL· GenBank· DDBJ
AAA30319.1
EMBL· GenBank· DDBJ
Genomic DNA
M94365
EMBL· GenBank· DDBJ
AAA30320.2
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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