Q06031 · GP63_CRIFA
- ProteinLeishmanolysin homolog
- Genegp63
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids653 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Plays an integral role during the infection of macrophages in the mammalian host.
Catalytic activity
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 276 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 277 | ||||
Binding site | 280 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 346 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | cell adhesion | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLeishmanolysin homolog
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Crithidia
Accessions
- Primary accessionQ06031
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, propeptide, chain, disulfide bond, glycosylation, lipidation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-44 | ||||
Propeptide | PRO_0000028652 | 45-113 | Activation peptide | ||
Chain | PRO_0000028653 | 114-628 | Leishmanolysin homolog | ||
Disulfide bond | 138↔155 | ||||
Disulfide bond | 203↔242 | ||||
Disulfide bond | 326↔398 | ||||
Glycosylation | 383 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 405↔468 | ||||
Glycosylation | 409 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 418↔437 | ||||
Disulfide bond | 427↔502 | ||||
Disulfide bond | 479↔524 | ||||
Disulfide bond | 529↔579 | ||||
Disulfide bond | 549↔572 | ||||
Glycosylation | 569 | N-linked (GlcNAc...) asparagine | |||
Lipidation | 628 | GPI-anchor amidated serine | |||
Propeptide | PRO_0000028654 | 629-653 | Removed in mature form | ||
Keywords
- PTM
PTM databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length653
- Mass (Da)69,171
- Last updated2010-10-05 v2
- Checksum263A1DA7568034B6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 590-625 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M94364 EMBL· GenBank· DDBJ | AAA30319.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M94365 EMBL· GenBank· DDBJ | AAA30320.2 EMBL· GenBank· DDBJ | Genomic DNA |