The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]StrainFVB/NTissueMammary tumor. C3CategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn.Hayashi T., Umemori H., Mishina M., Yamamoto T.View abstractCategoriesFunction, InteractionSourceMGI: 96892PubMedEurope PMCNature 397:72-76 (1999)Mapped to14
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.Hunter S., Burton E.A., Wu S.C., Anderson S.M.View abstractCategoriesInteractionSourceMGI: 96892PubMedEurope PMCJ Biol Chem 274:2097-2106 (1999)Mapped to42
SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity.Yang W., Mckenna S.D., Jiao H., Tabrizi M., Lynes M.A., Shultz L.D., Yi T.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCExp Hematol 26:1126-1132 (1998)Mapped to13
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.Satterthwaite A.B., Lowell C.A., Khan W.N., Sideras P., Alt F.W., Witte O.N.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCJ Exp Med 188:833-844 (1998)Mapped to8
A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.Meng F., Lowell C.A.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCEMBO J. 17:4391-4403 (1998)Cited in1Mapped to39
The molecular mechanism of B cell activation by toll-like receptor protein RP-105.Chan V.W., Mecklenbrauker I., Su I., Texido G., Leitges M., Carsetti R., Lowell C.A., Rajewsky K., Miyake K., Tarakhovsky A.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCJ Exp Med 188:93-101 (1998)Mapped to13
Abrogation of autoimmune disease in Lyn-deficient mice by the mutation of the Btk gene.Takeshita H., Taniuchi I., Kato J., Watanabe T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 96892PubMedEurope PMCInt Immunol 10:435-444 (1998)Mapped to8
Defective negative regulation of antigen receptor signaling in Lyn- deficient B lymphocytes.Chan V.W., Lowell C.A., DeFranco A.L.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCCurr. Biol. 8:545-553 (1998)Cited in2Mapped to73
Affinity maturation in Lyn kinase-deficient mice with defective germinal center formation.Kato J., Motoyama N., Taniuchi I., Takeshita H., Toyoda M., Masuda K., Watanabe T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 96892PubMedEurope PMCJ Immunol 160:4788-4795 (1998)Mapped to5
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.Cornall R.J., Cyster J.G., Hibbs M.L., Dunn A.R., Otipoby K.L., Clark E.A., Goodnow C.C.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCImmunity 8:497-508 (1998)Mapped to25
A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals.Nishizumi H., Horikawa K., Mlinaric-Rascan I., Yamamoto T.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCJ. Exp. Med. 187:1343-1348 (1998)Cited in1Mapped to73
Inhibition of the B cell by CD22: a requirement for Lyn.Smith K.G., Tarlinton D.M., Doody G.M., Hibbs M.L., Fearon D.T.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCJ. Exp. Med. 187:807-811 (1998)Cited in1Mapped to85
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.Schwartzberg P.L., Xing L., Hoffmann O., Lowell C.A., Garrett L., Boyce B.F., Varmus H.E.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCGenes Dev 11:2835-2844 (1997)Mapped to7
A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.Crowley M.T., Costello P.S., Fitzer-Attas C.J., Turner M., Meng F., Lowell C., Tybulewicz V.L., DeFranco A.L.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCJ Exp Med 186:1027-1039 (1997)Mapped to99+
A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5.Yasue T., Nishizumi H., Aizawa S., Yamamoto T., Miyake K., Mizoguchi C., Uehara S., Kikuchi Y., Takatsu K.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCProc Natl Acad Sci U S A 94:10307-10312 (1997)Mapped to18
Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.Chan V.W., Meng F., Soriano P., DeFranco A.L., Lowell C.A.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCImmunity 7:69-81 (1997)Cited in1Mapped to4
Lyn, a src-like tyrosine kinase.Hibbs M.L., Dunn A.R.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCInt J Biochem Cell Biol 29:397-400 (1997)Mapped to5
Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn.Meng F., Lowell C.A.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCJ Exp Med 185:1661-1670 (1997)Mapped to9
Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.Wang J., Koizumi T., Watanabe T.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCJ. Exp. Med. 184:831-838 (1996)Cited in1Mapped to9
Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.Nishizumi H., Yamamoto T.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCJ. Immunol. 158:2350-2355 (1997)Cited in1Mapped to4
Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.Costello P.S., Turner M., Walters A.E., Cunningham C.N., Bauer P.H., Downward J., Tybulewicz V.L.View abstractCategoriesFunctionSourceMGI: 96892PubMedEurope PMCOncogene 13:2595-2605 (1996)Mapped to20
Expression of tyrosine kinase gene in mouse thymic stromal cells.Rinke de Wit T.F., Izon D.J., Revilla C., Oosterwegel M., Bakker A.Q., van Ewijk W., Kruisbeek A.M.View abstractCategoriesSequencesSourceMGI: 96892PubMedEurope PMCInt Immunol 8:1787-1795 (1996)Mapped to42
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.Rawlings D.J., Scharenberg A.M., Park H., Wahl M.I., Lin S., Kato R.M., Fluckiger A.C., Witte O.N., Kinet J.P.View abstractCategoriesFunction, PTM / Processing, InteractionSourceMGI: 96892PubMedEurope PMCScience 271:822-825 (1996)Cited in2Mapped to99+
Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling.Tezuka T., Umemori H., Fusaki N., Yagi T., Takata M., Kurosaki T., Yamamoto T.View abstractCategoriesPTM / Processing, InteractionSourceMGI: 96892PubMedEurope PMCJ Exp Med 183:675-680 (1996)Mapped to13