The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueLungCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling.Techer H., Gopaul D., Heuze J., Bouzalmad N., Leray B., Vernet A., Mettling C., Moreaux J., Pasero P., Lin Y.L.View abstractAnnotationMRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling.SourceGeneRif: 4361PubMedEurope PMCNat Commun 15:5423-5423 (2024)Mapped to6
MRE11A: a novel negative regulator of human DNA mismatch repair.Du D., Yang Y., Zhang Y., Wang G., Chen L., Guan X., Rasmussen L.J., Liu D.View abstractAnnotationMRE11A: a novel negative regulator of human DNA mismatch repair.SourceGeneRif: 4361PubMedEurope PMCCell Mol Biol Lett 29:37-37 (2024)Mapped to6
MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.Cho M.G., Kumar R.J., Lin C.C., Boyer J.A., Shahir J.A., Fagan-Solis K., Simpson D.A., Fan C., Foster C.E.[...], Gupta G.P.View abstractAnnotationMRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.SourceGeneRif: 4361PubMedEurope PMCNature 625:585-592 (2024)Cited in2Mapped to21
Metabolic regulation of homologous recombination repair by MRE11 lactylation.Chen Y., Wu J., Zhai L., Zhang T., Yin H., Gao H., Zhao F., Wang Z., Yang X.[...], Yuan J.View abstractAnnotationMetabolic regulation of homologous recombination repair by MRE11 lactylation.SourceGeneRif: 4361PubMedEurope PMCCell 187:294-311 (2024)Cited in4Mapped to5
Disordered regions mediate the interaction of p53 and MRE11.Usluer S., Galhuber M., Khanna Y., Bourgeois B., Spreitzer E., Michenthaler H., Prokesch A., Madl T.View abstractAnnotationDisordered regions mediate the interaction of p53 and MRE11.SourceGeneRif: 4361PubMedEurope PMCBiochim Biophys Acta Mol Cell Res 1871:119654-119654 (2024)Mapped to99+
High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients.Azambuja D.B., E Gloria H.C., Montenegro G.E.S., Kalil A.N., Hoffmann J.S., Leguisamo N.M., Saffi J.View abstractAnnotationHigh Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients.CategoriesFunction, Disease & VariantsSourceGeneRif: 4361PubMedEurope PMCGenes (Basel) 14:1270-1270 (2023)Mapped to6
High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas.Jhan J.H., Ke H.L., Liang P.I., Hsu W.C., Lee Y.C., Lin H.H., Wu Y.R., Huang A.M., Lee H.Y.[...], Li W.M.View abstractAnnotationHigh MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCAppl Immunohistochem Mol Morphol 31:94-100 (2023)Mapped to6
RNF126-mediated MRE11 ubiquitination activates the DNA damage response and confers resistance of triple-negative breast cancer to radiotherapy.Liu W., Zheng M., Zhang R., Jiang Q., Du G., Wu Y., Yang C., Li F., Li W.[...], Chen C.View abstractAnnotationRNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCAdv. Sci. 10:e2203884-e2203884 (2023)Cited in3Mapped to14
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.Zeng X., Zhao F., Cui G., Zhang Y., Deshpande R.A., Chen Y., Deng M., Kloeber J.A., Shi Y.[...], Lou Z.View abstractAnnotationMETTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCNat Cancer 3:1088-1104 (2022)Mapped to9
Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.Zhang T., Yang H., Zhou Z., Bai Y., Wang J., Wang W.View abstractAnnotationCrosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.CategoriesFunction, PTM / ProcessingSourceGeneRif: 4361PubMedEurope PMCNat. Commun. 13:5133-5133 (2022)Cited in3Mapped to8
Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.Gut F., Kashammer L., Lammens K., Bartho J.D., Boggusch A.M., van de Logt E., Kessler B., Hopfner K.P.View abstractAnnotationStructural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.CategoriesStructureSourceGeneRif: 4361PubMedEurope PMCMol Cell 82:3513-3522.e6 (2022)Mapped to8
XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN- Induced Double-Strand DNA Breaks.Benjamin R., Banerjee A., Wu X., Geurink C., Buczek L., Eames D., Trimidal S.G., Pluth J.M., Schiller M.R.View abstractAnnotationXRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCInt J Mol Sci 23:593-593 (2022)Mapped to8
Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells.Batenburg N.L., Mersaoui S.Y., Walker J.R., Coulombe Y., Hammond-Martel I., Wurtele H., Masson J.Y., Zhu X.D.View abstractAnnotationCockayne syndrome group B protein regulates fork restart fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCNucleic Acids Res 49:12836-12854 (2021)Mapped to13
SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.Zhang J., Wu Q., Zhu L., Xie S., Tu L., Yang Y., Wu K., Zhao Y., Wang Y.[...], Zhang S.View abstractAnnotationSERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCCancer Lett 524:268-283 (2022)Mapped to13
Post-Translational Modification of MRE11: Its Implication in DDR and Diseases.Lu R., Zhang H., Jiang Y.N., Wang Z.Q., Sun L., Zhou Z.W.View abstractAnnotationPost-Translational Modification of MRE11: Its Implication in DDR and Diseases.CategoriesPTM / ProcessingSourceGeneRif: 4361PubMedEurope PMCGenes (Basel) 12:1158-1158 (2021)Mapped to6
Radiation-induced DNA damage and altered expression of p21, cyclin D1 and Mre11 genes in human fibroblast cell lines with different radiosensitivity.Bahreyni-Toossi M.T., Azimian H., Aghaee-Bakhtiari S.H., Mahmoudi M., Sadat-Darbandi M., Zafari N.View abstractAnnotationRadiation-induced DNA damage and altered expression of p21 cyclin D1 and Mre11 genes in human fibroblast cell lines with different radiosensitivity.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCMutat Res 823:111760-111760 (2021)Mapped to14
Role of Ki-67, MRE11, and PD-L1 as Predictive Biomarkers for Recurrence Pattern in Muscle-invasive Bladder Cancer.Fossum C.C., Xiong Y., Magliocco A., Daneshmand S., Aron M., Mouw K.W., Manojlovic Z., McCarthy S., Phuong C.[...], Ballas L.K.View abstractAnnotationRole of Ki-67 MRE11 and PD-L1 as Predictive Biomarkers for Recurrence Pattern in Muscle-invasive Bladder Cancer.CategoriesSequencesSourceGeneRif: 4361PubMedEurope PMCAnticancer Res 41:3851-3857 (2021)Mapped to13
MRN Complex and Cancer Risk: Old Bottles, New Wine.Elkholi I.E., Foulkes W.D., Rivera B.View abstractAnnotationMRN Complex and Cancer Risk: Old Bottles New Wine.CategoriesDisease & VariantsSourceGeneRif: 4361PubMedEurope PMCClin Cancer Res 27:5465-5471 (2021)Mapped to19
Yeast-based screening of cancer mutations in the DNA damage response protein Mre11 demonstrates importance of conserved capping domain residues.Harris C., Savas J., Ray S., Shanle E.K.View abstractAnnotationYeast-based screening of cancer mutations in the DNA damage response protein Mre11 demonstrates importance of conserved capping domain residues.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCMol Biol Rep 48:4107-4119 (2021)Mapped to7
MRE11 as a molecular signature and therapeutic target for cancer treatment with radiotherapy.Wang Y.Y., Hung A.C., Lo S., Hsieh Y.C., Yuan S.F.View abstractAnnotationMRE11 as a molecular signature and therapeutic target for cancer treatment with radiotherapy.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCCancer Lett 514:1-11 (2021)Mapped to6
MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner.Wang Y.Y., Chen Y.K., Lo S., Chi T.C., Chen Y.H., Hu S.C., Chen Y.W., Jiang S.S., Tsai F.Y.[...], Yuan S.F.View abstractAnnotationMRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCOncogene 40:3510-3532 (2021)Mapped to6
Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C.Rahman S., Beikzadeh M., Latham M.P.View abstractAnnotationBiochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C.CategoriesFunction, Disease & VariantsSourceGeneRif: 4361PubMedEurope PMCSci Rep 11:7089-7089 (2021)Mapped to6
Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma.Murakami T., Shoji Y., Nishi T., Chang S.C., Jachimowicz R.D., Hoshimoto S., Ono S., Shiloh Y., Takeuchi H.[...], Bustos M.A.View abstractAnnotationRegulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCMol Oncol 15:1069-1087 (2021)Mapped to9
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.Lee J.H., Ryu S.W., Ender N.A., Paull T.T.View abstractAnnotationPoly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.CategoriesFunctionSourceGeneRif: 4361PubMedEurope PMCMol Cell 81:1515-1533.e5 (2021)Mapped to6