Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems.Podsypanina K., Ellenson L.H., Nemes A., Gu J., Tamura M., Yamada K.M., Cordon-Cardo C., Catoretti G., Fisher P.E., Parsons R.View abstractCategoriesFunction, ExpressionSourceMGI: 97810PubMedEurope PMCProc Natl Acad Sci U S A 96:1563-1568 (1999)Mapped to31
Beta-selection of immature thymocytes is less dependent on CD45 tyrosinephosphatase.Sato T., Kishihara K., Mak T.W., Habu S.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCImmunol Lett 64:133-138 (1998)Mapped to13
Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression.Oliveira-dos-Santos A.J., Penninger J.M., Rieker-Geley T., Matsumoto G., Mak T.M., Wick G.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCEur J Immunol 28:2882-2892 (1998)Mapped to99+
The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages.Roach T.I., Slater S.E., White L.S., Zhang X., Majerus P.W., Brown E.J., Thomas M.L.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCCurr Biol 8:1035-1038 (1998)Mapped to17
Differential requirements of CD45 protein tyrosine phosphatase for cytolytic activities and intrathymic and extrathymic development of intestinal intraepithelial lymphocytes.Yada S., Kishihara K., Kong Y.Y., Nomoto K.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCJ Immunol 161:2208-2216 (1998)Mapped to13
CD45 and RPTPalpha display different protein tyrosine phosphatase activities in T lymphocytes.Ng D.H., Jabali M.D., Maiti A., Borodchak P., Harder K.W., Brocker T., Malissen B., Jirik F.R., Johnson P.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCBiochem J 327:867-876 (1997)Mapped to13
Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice.Motoyama J., Kitajima K., Kojima M., Kondo S., Takeuchi T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 97810PubMedEurope PMCMech. Dev. 66:27-37 (1997)Cited in1Mapped to29
Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase.Gong Q., White L., Johnson R., White M., Negishi I., Thomas M., Chan A.C.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCImmunity 7:369-377 (1997)Mapped to16
The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.Penninger J.M., Sirard C., Mittrucker H.W., Chidgey A., Kozieradzki I., Nghiem M., Hakem A., Kimura T., Timms E.[...], Mak T.W.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCImmunity 7:243-254 (1997)Mapped to30
The motheaten mutation rescues B cell signaling and development in CD45- deficient mice.Pani G., Siminovitch K.A., Paige C.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 97810PubMedEurope PMCJ Exp Med 186:581-588 (1997)Mapped to41
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.Wiest D.L., Ashe J.M., Howcroft T.K., Lee H.-M., Kemper D.M., Negishi I., Singer D.S., Singer A., Abe R.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 97810PubMedEurope PMCImmunity 6:663-671 (1997)Cited in1Mapped to61
CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion.Roach T., Slater S., Koval M., White L., Cahir McFarland E.D., Okumura M., Thomas M., Brown E.View abstractCategoriesFunction, PTM / Processing, InteractionSourceMGI: 97810PubMedEurope PMCCurr Biol 7:408-417 (1997)Mapped to9
Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.Stone J.D., Conroy L.A., Byth K.F., Hederer R.A., Howlett S., Takemoto Y., Holmes N., Alexander D.R.View abstractCategoriesFunction, PTM / Processing, InteractionSourceMGI: 97810PubMedEurope PMCJ Immunol 158:5773-5782 (1997)Mapped to9
Alterations in the level of CD45 surface expression affect the outcome of thymic selection.Wallace V.A., Penninger J.M., Kishihara K., Timms E., Shahinian A., Pircher H., Kundig T.M., Ohashi P.S., Mak T.W.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCJ Immunol 158:3205-3214 (1997)Mapped to9
FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse.Helou K., Das A.T., Lamers W.H., Hoovers J.M., Szpirer C., Szpirer J., Klinga-Levan K., Levan G.CategoriesFunction, SequencesSourceMGI: 97810PubMedEurope PMCMamm Genome 8:362-364 (1997)Mapped to56
T-cell-independent antiviral B cell responses in CD45-deficient mice.Bachmann M.F., Kundig T.M., Speiser D.E., McKall-Faienza K., Kishara K., Mak T.W., Ohashi P.S.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCCell Immunol 175:12-15 (1997)Mapped to9
Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes.Li T., Ramirez K., Palacios R.View abstractCategoriesFunction, ExpressionSourceMGI: 97810PubMedEurope PMCCell Growth Differ 7:107-114 (1996)Mapped to52
Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45.Cyster J.G., Healy J.I., Kishihara K., Mak T.W., Thomas M.L., Goodnow C.C.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCNature 381:325-328 (1996)Mapped to9
CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.Byth K.F., Conroy L.A., Howlett S., Smith A.J., May J., Alexander D.R., Holmes N.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 97810PubMedEurope PMCJ Exp Med 183:1707-1718 (1996)Mapped to37
Genetic mapping of the gene encoding the alpha1 subunit of neuronal calcium channels.Lyu M., Kozak C.A., Chin H.CategoriesFunction, SequencesSourceMGI: 97810PubMedEurope PMCMamm Genome 7:326-327 (1996)Mapped to35
Differential requirements of CD45 for lymphocyte development and function.Kong Y.Y., Kishihara K., Sumichika H., Nakamura T., Kaneko M., Nomoto K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 97810PubMedEurope PMCEur J Immunol 25:3431-3436 (1995)Mapped to44
Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells.Haidl I.D., Ng D.H., Rothenberger S., Johnson P., Jefferies W.A.View abstractCategoriesFunction, ExpressionSourceMGI: 97810PubMedEurope PMCEur J Immunol 25:3370-3374 (1995)Mapped to9
Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice.Takai T., Ono M., Hikida M., Ohmori H., Ravetch J.V.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 97810PubMedEurope PMCNature 379:346-349 (1996)Mapped to43
Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.Benatar T., Carsetti R., Furlonger C., Kamalia N., Mak T., Paige C.J.View abstractCategoriesFunctionSourceMGI: 97810PubMedEurope PMCJ Exp Med 183:329-334 (1996)Mapped to9
Normal B lymphocyte development but impaired T cell maturation in CD45- exon6 protein tyrosine phosphatase-deficient mice.Kishihara K., Penninger J., Wallace V.A., Kundig T.M., Kawai K., Wakeham A., Timms E., Pfeffer K., Ohashi P.S., Thomas M.L.View abstractCategoriesFunction, Sequences, Phenotypes & VariantsSourceMGI: 97810PubMedEurope PMCCell 74:143-156 (1993)Mapped to9