DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53.Wang P., Wu B., You S., Lu S., Xiong S., Zou Y., Jia P., Guo X., Zhang Y.[...], Zhang N.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCInt J Biol Sci 18:409-425 (2022)Mapped to14
Adipose-derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy.Lv M., Zhang S., Jiang B., Cao S., Dong Y., Cao L., Guo S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCFASEB J 35:e21709-e21709 (2021)Mapped to14
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.Silva-Pinheiro P., Pardo-Hernandez C., Reyes A., Tilokani L., Mishra A., Cerutti R., Li S., Rozsivalova D.H., Valenzuela S.[...], Viscomi C.View abstractAnnotationDNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 18975, MGI: 1196389PubMedEurope PMCNucleic Acids Res 49:5230-5248 (2021)Mapped to18
Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon.Stamp C., Whitehall J.C., Smith A.L.M., Houghton D., Bradshaw C., Stoll E.A., Blain A.P., Turnbull D.M., Greaves L.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCAging Cell 20:e13321-e13321 (2021)Mapped to18
Attempts to understand the mechanisms of mitochondrial diseases: The reverse genetics of mouse models for mitochondrial disease.Ishikawa K., Nakada K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCBiochim Biophys Acta Gen Subj 1865:129835-129835 (2021)Mapped to45
Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing.Basu S., Xie X., Uhler J.P., Hedberg-Oldfors C., Milenkovic D., Baris O.R., Kimoloi S., Matic S., Stewart J.B.[...], Larsson E.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCPLoS Genet 16:e1009242-e1009242 (2020)Mapped to22
Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition.Kuroki R., Murata Y., Fuke S., Nakachi Y., Nakashima J., Kujoth G.C., Prolla T.A., Bundo M., Kato T., Iwamoto K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCFront Genet 11:519206-519206 (2020)Mapped to14
Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD<sup>+</sup> redox.Yang L., Lin X., Tang H., Fan Y., Zeng S., Jia L., Li Y., Shi Y., He S.[...], Liu X.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCAging Cell 19:e13206-e13206 (2020)Mapped to14
Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss.Dobson P.F., Dennis E.P., Hipps D., Reeve A., Laude A., Bradshaw C., Stamp C., Smith A., Deehan D.J.[...], Greaves L.C.View abstractAnnotationMitochondrial dysfunction impairs osteogenesis increases osteoclast activity and accelerates age related bone loss.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 18975, MGI: 1196389PubMedEurope PMCSci Rep 10:11643-11643 (2020)Mapped to14
Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging.Maclaine K.D., Stebbings K.A., Llano D.A., Rhodes J.S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCPLoS One 15:e0226860-e0226860 (2020)Mapped to14
Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase.McLaughlin K.L., Kew K.A., McClung J.M., Fisher-Wellman K.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCSci Rep 10:3603-3603 (2020)Mapped to14
Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features.Geurts J., Nasi S., Distel P., Muller-Gerbl M., Prolla T.A., Kujoth G.C., Walker U.A., Hugle T.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCSci Rep 10:1296-1296 (2020)Mapped to14
Deleterious mtDNA mutations are common in mature oocytes.Ma H., Hayama T., Van Dyken C., Darby H., Koski A., Lee Y., Gutierrez N.M., Yamada S., Li Y.[...], Mitalipov S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCBiol Reprod 102:607-619 (2020)Mapped to14
Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.Kim M.J., Haroon S., Chen G.D., Ding D., Wanagat J., Liu L., Zhang Y., White K., Park H.J.[...], Someya S.View abstractAnnotation17-month-old Polg(mut/mut) mice displayed a profound loss of spiral ganglion neurons in the cochlea.CategoriesPhenotypes & VariantsSourceGeneRif: 18975, MGI: 1196389PubMedEurope PMCExp Gerontol 125:110675-110675 (2019)Mapped to14
Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.Woodall B.P., Orogo A.M., Najor R.H., Cortez M.Q., Moreno E.R., Wang H., Divakaruni A.S., Murphy A.N., Gustafsson A.B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCJCI Insight 5:127713-127713 (2019)Mapped to29
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.Anderson R., Lagnado A., Maggiorani D., Walaszczyk A., Dookun E., Chapman J., Birch J., Salmonowicz H., Ogrodnik M.[...], Passos J.F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCEMBO J 38:e100492-e100492 (2019)Mapped to28
Calorie restriction does not influence oocyte quality in oocytes from POLG mitochondrial mutator mice.Faraci C., Jin J., Woods D.C.View abstractAnnotationCR benefits oocyte quality and fertility outcomes in naturally aged female mice it does not sufficiently improve oocyte quality in PolgD257A/D257ACategoriesFunction, Phenotypes & VariantsSourceGeneRif: 18975, MGI: 1196389PubMedEurope PMCPLoS One 13:e0204373-e0204373 (2018)Mapped to14
Parkin and PINK1 mitigate STING-induced inflammation.Sliter D.A., Martinez J., Hao L., Chen X., Sun N., Fischer T.D., Burman J.L., Li Y., Zhang Z.[...], Youle R.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCNature 561:258-262 (2018)Mapped to66
Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.Faraci C., Annis S., Jin J., Li H., Khrapko K., Woods D.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCReproduction 156:185-194 (2018)Mapped to14
A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.Simard M.L., Mourier A., Greaves L.C., Taylor R.W., Stewart J.B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCJ Pathol 245:311-323 (2018)Mapped to29
The presence of rNTPs decreases the speed of mitochondrial DNA replication.Forslund J.M.E., Pfeiffer A., Stojkovic G., Wanrooij P.H., Wanrooij S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCPLoS Genet 14:e1007315-e1007315 (2018)Mapped to14
Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load.Jiang M., Kauppila T.E.S., Motori E., Li X., Atanassov I., Folz-Donahue K., Bonekamp N.A., Albarran-Gutierrez S., Stewart J.B., Larsson N.G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCCell Metab 26:429-436.e4 (2017)Mapped to19
Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.Someya S., Kujoth G.C., Kim M.J., Hacker T.A., Vermulst M., Weindruch R., Prolla T.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCPLoS One 12:e0171159-e0171159 (2017)Mapped to14
Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.Chung H.K., Ryu D., Kim K.S., Chang J.Y., Kim Y.K., Yi H.S., Kang S.G., Choi M.J., Lee S.E.[...], Shong M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCJ. Cell Biol. 216:149-165 (2017)Cited in1Mapped to29
A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.Kauppila J.H.K., Baines H.L., Bratic A., Simard M.L., Freyer C., Mourier A., Stamp C., Filograna R., Larsson N.G.[...], Stewart J.B.View abstractCategoriesSequences, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCCell Rep 16:2980-2990 (2016)Cited in13Mapped to18