The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]StrainC57BL/6TissueBrainCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Localization by fluorescence in situ hybridization (FISH) of human mitochondrial polymerase gamma (POLG) to human chromosome band 15q24-->q26, and of mouse mitochondrial polymerase gamma (Polg) to mouse chromosome band 7E, with confirmation by direct sequence analysis of bacterial artificial chromosomes (BACs).Zullo S.J., Butler L., Zahorchak R.J., Macville M., Wilkes C., Merril C.R.View abstractCategoriesSequencesSourceMGI: 1196389PubMedEurope PMCCytogenet Cell Genet 78:281-284 (1997)Mapped to14
Absence of both MGME1 and POLG EXO abolishes mtDNA whereas absence of either creates unique mtDNA duplications.Gonzalez C.D., Nissanka N., Van Booven D., Griswold A.J., Moraes C.T.View abstractAnnotationAbsence of both MGME1 and POLG EXO abolishes mtDNA whereas absence of either creates unique mtDNA duplications.SourceGeneRif: 18975PubMedEurope PMCJ Biol Chem 300:107128-107128 (2024)Mapped to6
Mitochondrial Dysfunction and Protein Homeostasis in Aging: Insights from a Premature-Aging Mouse Model.Ross J.M., Olson L., Coppotelli G.View abstractSourceMGI: 1196389PubMedEurope PMCBiomolecules 14:162-162 (2024)Mapped to14
NAD<sup>+</sup> dependent UPR<sup>mt</sup> activation underlies intestinal aging caused by mitochondrial DNA mutations.Yang L., Ruan Z., Lin X., Wang H., Xin Y., Tang H., Hu Z., Zhou Y., Wu Y.[...], Liu X.View abstractSourceMGI: 1196389PubMedEurope PMCNat Commun 15:546-546 (2024)Mapped to18
Effective differentiation of double negative thymocytes requires high fidelity replication of mitochondrial DNA in an age dependent manner.Limper C.B., Bondah N., Zhu D., Villanueva A.N., Chukwukere U.K., Huang W., August A.View abstractSourceMGI: 1196389PubMedEurope PMCFront Immunol 14:1128626-1128626 (2023)Mapped to14
The Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in PolgA<sup>D257A/D257A</sup> Mitochondrial Mutator Mice.Scott L., Karuppagounder S.S., Neifert S., Kang B.G., Wang H., Dawson V.L., Dawson T.M.View abstractAnnotationThe Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in PolgA[D257A/D257A]CategoriesFunctionSourceGeneRif: 18975PubMedEurope PMCJ Neurosci 42:9263-9277 (2022)Mapped to16
DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53.Wang P., Wu B., You S., Lu S., Xiong S., Zou Y., Jia P., Guo X., Zhang Y.[...], Zhang N.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCInt J Biol Sci 18:409-425 (2022)Mapped to14
Adipose-derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy.Lv M., Zhang S., Jiang B., Cao S., Dong Y., Cao L., Guo S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCFASEB J 35:e21709-e21709 (2021)Mapped to14
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.Silva-Pinheiro P., Pardo-Hernandez C., Reyes A., Tilokani L., Mishra A., Cerutti R., Li S., Rozsivalova D.H., Valenzuela S.[...], Viscomi C.View abstractAnnotationDNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 18975, MGI: 1196389PubMedEurope PMCNucleic Acids Res 49:5230-5248 (2021)Mapped to18
Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon.Stamp C., Whitehall J.C., Smith A.L.M., Houghton D., Bradshaw C., Stoll E.A., Blain A.P., Turnbull D.M., Greaves L.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCAging Cell 20:e13321-e13321 (2021)Mapped to18
Attempts to understand the mechanisms of mitochondrial diseases: The reverse genetics of mouse models for mitochondrial disease.Ishikawa K., Nakada K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCBiochim Biophys Acta Gen Subj 1865:129835-129835 (2021)Mapped to45
Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing.Basu S., Xie X., Uhler J.P., Hedberg-Oldfors C., Milenkovic D., Baris O.R., Kimoloi S., Matic S., Stewart J.B.[...], Larsson E.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCPLoS Genet 16:e1009242-e1009242 (2020)Mapped to22
Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition.Kuroki R., Murata Y., Fuke S., Nakachi Y., Nakashima J., Kujoth G.C., Prolla T.A., Bundo M., Kato T., Iwamoto K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCFront Genet 11:519206-519206 (2020)Mapped to14
Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD<sup>+</sup> redox.Yang L., Lin X., Tang H., Fan Y., Zeng S., Jia L., Li Y., Shi Y., He S.[...], Liu X.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCAging Cell 19:e13206-e13206 (2020)Mapped to14
Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss.Dobson P.F., Dennis E.P., Hipps D., Reeve A., Laude A., Bradshaw C., Stamp C., Smith A., Deehan D.J.[...], Greaves L.C.View abstractAnnotationMitochondrial dysfunction impairs osteogenesis increases osteoclast activity and accelerates age related bone loss.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 18975, MGI: 1196389PubMedEurope PMCSci Rep 10:11643-11643 (2020)Mapped to14
Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging.Maclaine K.D., Stebbings K.A., Llano D.A., Rhodes J.S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCPLoS One 15:e0226860-e0226860 (2020)Mapped to14
Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase.McLaughlin K.L., Kew K.A., McClung J.M., Fisher-Wellman K.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCSci Rep 10:3603-3603 (2020)Mapped to14
Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features.Geurts J., Nasi S., Distel P., Muller-Gerbl M., Prolla T.A., Kujoth G.C., Walker U.A., Hugle T.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCSci Rep 10:1296-1296 (2020)Mapped to14
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units.Giorgetti E., Panesar M., Zhang Y., Joller S., Ronco M., Obrecht M., Lambert C., Accart N., Beckmann N.[...], Nash M.View abstractSourceMGI: 1196389PubMedEurope PMCCell Rep 29:1539-1554.e7 (2019)Mapped to27
Deleterious mtDNA mutations are common in mature oocytes.Ma H., Hayama T., Van Dyken C., Darby H., Koski A., Lee Y., Gutierrez N.M., Yamada S., Li Y.[...], Mitalipov S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCBiol Reprod 102:607-619 (2020)Mapped to14
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis.Chung K.P., Hsu C.L., Fan L.C., Huang Z., Bhatia D., Chen Y.J., Hisata S., Cho S.J., Nakahira K.[...], Choi A.M.K.View abstractCategoriesFunctionSourceMGI: 1196389PubMedEurope PMCNat Commun 10:3390-3390 (2019)Mapped to32
Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.Kim M.J., Haroon S., Chen G.D., Ding D., Wanagat J., Liu L., Zhang Y., White K., Park H.J.[...], Someya S.View abstractAnnotation17-month-old Polg(mut/mut) mice displayed a profound loss of spiral ganglion neurons in the cochlea.CategoriesPhenotypes & VariantsSourceGeneRif: 18975, MGI: 1196389PubMedEurope PMCExp Gerontol 125:110675-110675 (2019)Mapped to14
Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.Woodall B.P., Orogo A.M., Najor R.H., Cortez M.Q., Moreno E.R., Wang H., Divakaruni A.S., Murphy A.N., Gustafsson A.B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCJCI Insight 5:127713-127713 (2019)Mapped to29
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.Anderson R., Lagnado A., Maggiorani D., Walaszczyk A., Dookun E., Chapman J., Birch J., Salmonowicz H., Ogrodnik M.[...], Passos J.F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1196389PubMedEurope PMCEMBO J 38:e100492-e100492 (2019)Mapped to28