Q05718 · IBP6_BOVIN

  • Protein
    Insulin-like growth factor-binding protein 6
  • Gene
    IGFBP6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionfibronectin binding
Molecular Functioninsulin-like growth factor I binding
Molecular Functioninsulin-like growth factor II binding
Biological Processcell migration
Biological Processpositive regulation of MAPK cascade
Biological Processregulation of insulin-like growth factor receptor signaling pathway

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Insulin-like growth factor-binding protein 6
  • Short names
    IBP-6; IGF-binding protein 6; IGFBP-6

Gene names

    • Name
      IGFBP6

Organism names

  • Taxonomic identifier
  • Strain
    • Crossbred X Angus
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    Q05718
  • Secondary accessions
    • Q2YDN5
    • Q865L3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_000015277626-237Insulin-like growth factor-binding protein 6
Disulfide bond27↔30
Disulfide bond38↔42
Disulfide bond55↔61
Disulfide bond69↔82
Disulfide bond76↔102
Disulfide bond159↔186
Disulfide bond197↔208
Disulfide bond210↔231

Post-translational modification

O-glycosylated.

Keywords

Proteomic databases

Interaction

Subunit

Interacts (via C-terminal domain) with PHB2.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain26-105IGFBP N-terminal
Region101-158Disordered
Compositional bias112-153Polar residues
Domain156-231Thyroglobulin type-1
Region215-237Disordered
Compositional bias222-237Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    237
  • Mass (Da)
    24,967
  • Last updated
    2006-05-30 v2
  • Checksum
    3502EBDC21DE89AA
MTPHRLLPPLLLTLLLAARPGGALARCPGCGQGVSAGCPGGCAEEEDGGPAAEGCAEAGGCLRREGQQCGVYTPNCAPGLQCQPPEKEDLPLRALLQGRGRCGRARTPSGENPKESKPQAGTARSQDVNRRDQQRNSGTSTTPSRSNSGGVQDTEMGPCRKHLDSVLQQLQTEVFRGAHTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVERMGQPLPGSSEGGDGSSLCPTGSSG

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias112-153Polar residues
Sequence conflict188in Ref. 1; AAI10142
Compositional bias222-237Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC110141
EMBL· GenBank· DDBJ
AAI10142.1
EMBL· GenBank· DDBJ
mRNA
S52774
EMBL· GenBank· DDBJ
AAB24875.2
EMBL· GenBank· DDBJ
mRNA
AY197339
EMBL· GenBank· DDBJ
AAO45612.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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