Q05588 · UPAR_BOVIN
- ProteinUrokinase plasminogen activator surface receptor
- GenePLAUR
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids330 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical part of cell | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Molecular Function | zymogen binding |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUrokinase plasminogen activator surface receptor
- Short namesU-PAR; uPAR
- CD Antigen Name
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionQ05588
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MGQPLLLLLLVYTYIPGSWG | ||||||
Chain | PRO_0000036086 | 21-?300 | Urokinase plasminogen activator surface receptor | |||
Sequence: LRCLQCENTTSCSVEECTPGQDLCRTTVLSVWEGGNEMNVVRKGCTHPDKTNRSMSYRAADQIITLSETVCRSDLCNKPNPGRDATVSRNRYLECASCSSTDLSCERGWDQTMQCLKSRDQCVDVITHRSLKENPGDERHIRGCGILPGCPGPTGFHNNHTFHFLRCCNTTKCNAGSVLELQNLPPNGLQCYSCEGNGAHRCSSEETFLIDCRGPMNQCLEATGTKGLRNPSYTIRGCAAPSWCQSLHVAEAFDLTHVNVSCCTGSGCNHPARDDQPGKG | ||||||
Disulfide bond | 23↔44 | |||||
Sequence: CLQCENTTSCSVEECTPGQDLC | ||||||
Disulfide bond | 26↔32 | |||||
Sequence: CENTTSC | ||||||
Glycosylation | 28 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 37↔65 | |||||
Sequence: CTPGQDLCRTTVLSVWEGGNEMNVVRKGC | ||||||
Glycosylation | 72 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 91↔96 | |||||
Sequence: CRSDLC | ||||||
Disulfide bond | 115↔142 | |||||
Sequence: CASCSSTDLSCERGWDQTMQCLKSRDQC | ||||||
Disulfide bond | 118↔125 | |||||
Sequence: CSSTDLSC | ||||||
Disulfide bond | 135↔164 | |||||
Sequence: CLKSRDQCVDVITHRSLKENPGDERHIRGC | ||||||
Disulfide bond | 170↔187 | |||||
Sequence: CPGPTGFHNNHTFHFLRC | ||||||
Glycosylation | 179 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 188↔193 | |||||
Sequence: CNTTKC | ||||||
Glycosylation | 189 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 211↔239 | |||||
Sequence: CYSCEGNGAHRCSSEETFLIDCRGPMNQC | ||||||
Disulfide bond | 214↔222 | |||||
Sequence: CEGNGAHRC | ||||||
Disulfide bond | 232↔258 | |||||
Sequence: CRGPMNQCLEATGTKGLRNPSYTIRGC | ||||||
Disulfide bond | 264↔282 | |||||
Sequence: CQSLHVAEAFDLTHVNVSC | ||||||
Glycosylation | 279 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 283↔288 | |||||
Sequence: CTGSGC | ||||||
Lipidation | 300 | GPI-anchor amidated glycine | ||||
Sequence: G | ||||||
Propeptide | PRO_0000036087 | ?301-330 | Removed in mature form | |||
Sequence: GAPKTSPAHLSFFVSLLLTARLWGATLLCT |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity).
Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (By similarity).
The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (By similarity).
Interacts with CD82; this interaction prevents PLAUR from binding to its high affinity ligand PLAU (By similarity).
Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (By similarity).
The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (By similarity).
Interacts with CD82; this interaction prevents PLAUR from binding to its high affinity ligand PLAU (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-112 | UPAR/Ly6 1 | ||||
Sequence: LRCLQCENTTSCSVEECTPGQDLCRTTVLSVWEGGNEMNVVRKGCTHPDKTNRSMSYRAADQIITLSETVCRSDLCNKPNPGRDATVSRNRY | ||||||
Domain | 113-208 | UPAR/Ly6 2 | ||||
Sequence: LECASCSSTDLSCERGWDQTMQCLKSRDQCVDVITHRSLKENPGDERHIRGCGILPGCPGPTGFHNNHTFHFLRCCNTTKCNAGSVLELQNLPPNG | ||||||
Domain | 209-300 | UPAR/Ly6 3 | ||||
Sequence: LQCYSCEGNGAHRCSSEETFLIDCRGPMNQCLEATGTKGLRNPSYTIRGCAAPSWCQSLHVAEAFDLTHVNVSCCTGSGCNHPARDDQPGKG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length330
- Mass (Da)35,989
- Last updated1994-02-01 v1
- Checksum75E8BFAD1CE39C5C
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9TUB7 | A0AAA9TUB7_BOVIN | PLAUR | 322 | ||
A0A3Q1LZR0 | A0A3Q1LZR0_BOVIN | PLAUR | 323 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L03545 EMBL· GenBank· DDBJ | AAA30802.1 EMBL· GenBank· DDBJ | mRNA | ||
S70635 EMBL· GenBank· DDBJ | AAB30120.1 EMBL· GenBank· DDBJ | mRNA | ||
BC134754 EMBL· GenBank· DDBJ | AAI34755.1 EMBL· GenBank· DDBJ | mRNA | ||
BC142002 EMBL· GenBank· DDBJ | AAI42003.1 EMBL· GenBank· DDBJ | mRNA |