Q05588 · UPAR_BOVIN

  • Protein
    Urokinase plasminogen activator surface receptor
  • Gene
    PLAUR
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical part of cell
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionzymogen binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urokinase plasminogen activator surface receptor
  • Short names
    U-PAR; uPAR
  • CD Antigen Name
    • CD87

Gene names

    • Name
      PLAUR

Organism names

  • Taxonomic identifier
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    Q05588
  • Secondary accessions
    • A5PJ83

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_000003608621-?300Urokinase plasminogen activator surface receptor
Disulfide bond23↔44
Disulfide bond26↔32
Glycosylation28N-linked (GlcNAc...) asparagine
Disulfide bond37↔65
Glycosylation72N-linked (GlcNAc...) asparagine
Disulfide bond91↔96
Disulfide bond115↔142
Disulfide bond118↔125
Disulfide bond135↔164
Disulfide bond170↔187
Glycosylation179N-linked (GlcNAc...) asparagine
Disulfide bond188↔193
Glycosylation189N-linked (GlcNAc...) asparagine
Disulfide bond211↔239
Disulfide bond214↔222
Disulfide bond232↔258
Disulfide bond264↔282
Glycosylation279N-linked (GlcNAc...) asparagine
Disulfide bond283↔288
Lipidation300GPI-anchor amidated glycine
PropeptidePRO_0000036087?301-330Removed in mature form

Keywords

Proteomic databases

PTM databases

Expression

Induction

By retinoic acid.

Gene expression databases

Interaction

Subunit

Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity).
Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (By similarity).
The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (By similarity).
Interacts with CD82; this interaction prevents PLAUR from binding to its high affinity ligand PLAU (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-112UPAR/Ly6 1
Domain113-208UPAR/Ly6 2
Domain209-300UPAR/Ly6 3

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    330
  • Mass (Da)
    35,989
  • Last updated
    1994-02-01 v1
  • Checksum
    75E8BFAD1CE39C5C
MGQPLLLLLLVYTYIPGSWGLRCLQCENTTSCSVEECTPGQDLCRTTVLSVWEGGNEMNVVRKGCTHPDKTNRSMSYRAADQIITLSETVCRSDLCNKPNPGRDATVSRNRYLECASCSSTDLSCERGWDQTMQCLKSRDQCVDVITHRSLKENPGDERHIRGCGILPGCPGPTGFHNNHTFHFLRCCNTTKCNAGSVLELQNLPPNGLQCYSCEGNGAHRCSSEETFLIDCRGPMNQCLEATGTKGLRNPSYTIRGCAAPSWCQSLHVAEAFDLTHVNVSCCTGSGCNHPARDDQPGKGGAPKTSPAHLSFFVSLLLTARLWGATLLCT

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9TUB7A0AAA9TUB7_BOVINPLAUR322
A0A3Q1LZR0A0A3Q1LZR0_BOVINPLAUR323

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L03545
EMBL· GenBank· DDBJ
AAA30802.1
EMBL· GenBank· DDBJ
mRNA
S70635
EMBL· GenBank· DDBJ
AAB30120.1
EMBL· GenBank· DDBJ
mRNA
BC134754
EMBL· GenBank· DDBJ
AAI34755.1
EMBL· GenBank· DDBJ
mRNA
BC142002
EMBL· GenBank· DDBJ
AAI42003.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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